Tedizolid Phosphate
Brand Names: Sivextro
Methodology & AI Transparency ⓘ
Tedizolid Phosphate Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Listed in the U.S.
- 2 Real-world patient consensus: 94% patient "Worth It" rating across 9 anonymous logs for Tedizolid Phosphate (RxNorm RXN-67919040-3223).
- 3 Typical cash cost range: Public pharmacy ledger: $185.00 low cash benchmark vs. $453.25 chain retail average ($445.4998/unit CMS NADAC).
- 4 Top reported side effects / signs: Primary clinical safety signals tracked in FAERS for Tedizolid Phosphate include diarrhea (8.7%), nausea (8.5%), headache (6.6%).
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Tedizolid Phosphate Mechanism, CYP450 Pathways & DailyMed Monograph
Listed in the U.S. FDA National Drug Code Registry (67919-040, 67919-041), Tedizolid Phosphate serves as a intravenous-route prescription oxazolidinone antibacterial (200 mg/4mL Injection, Powder, Lyophilized, for Solution and 200 mg/1 Tablet, Film Coated, manufactured/labeled by Merck Sharp & Dohme LLC) utilized in evidence-based specialty and primary care protocols.
Upon intravenous-route administration of 200 mg/4mL Injection, Powder, Lyophilized, for Solution and 200 mg/1 Tablet, Film Coated, Tedizolid Phosphate (manufactured/labeled by Merck Sharp & Dohme LLC; NDC 67919-040, 67919-041) engages oxazolidinone antibacterial biochemical pathways to achieve steady-state therapeutic response balanced against organ-specific metabolic elimination.
Systemic exposure to Tedizolid Phosphate reflects Complete (~100%) parenteral systemic delivery for Tedizolid Phosphate (200 mg/4mL Injection, Powder, Lyophilized, for Solution) absorption kinetics and hepatic enzymatic processing and renal clearance proportional to creatinine clearance (tedizolid phosphate), sustaining receptor engagement across a Biphasic clearance with 11–23 hr terminal t½ under Tedizolid Phosphate maintenance half-life window (rapid intravascular/parenteral onset within 15–45 minutes after tedizolid phosphate administration response profile).
Dosing protocols (200 mg/4mL Injection, Powder, Lyophilized, for Solution or 200 mg/1 Tablet, Film Coated) balance efficacy (94.00% patient satisfaction across 9 logs) against diarrhea (8.7% of reports), nausea (8.5% of reports), headache (6.6% of reports), with strict avoidance in known hypersensitivity to tedizolid phosphate or structurally related oxazolidinone antibacterial compounds; concomitant contra-labeled cyp/transporter therapies during active tedizolid phosphate administration.
Avoid overlapping oxazolidinone antibacterial prescriptions alongside Tedizolid Phosphate to prevent cumulative receptor toxicity.
Botanical enzyme modulators may alter oral first-pass exposure of Tedizolid Phosphate; disclose all supplements.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Known hypersensitivity to Tedizolid Phosphate or structurally related oxazolidinone antibacterial compounds
- Concomitant contra-labeled CYP/transporter therapies during active Tedizolid Phosphate administration
Logged Side-Effect Incidence (9 Reports)
Tedizolid Phosphate Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Tedizolid Phosphate)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| Can This Approach Help? Inside the Latest Research on A Phase 3 Study of the safety and real-world benefits of Tedizolid Phosphate in The results of this study provide evidence to support the use of tedizolid phosphate to treat ABSSSI caused by Gram-positive pathogens in children patients from 28 days to <12 years of age. The Pediatric infectious disease journal • 2025-06-01 • Phase III Randomized Trial | N = 100 | 82/100 | PMID 40233296 ↗ |
| Can This Approach Help? Inside the Latest Research on Safety and real-world benefits of Oral and/or Intravenous Tedizolid Phosphate Tedizolid demonstrated safety and real-world benefits similar to comparators for the treatment of ABSSSIs in adolescents. The Pediatric infectious disease journal • 2021-03-01 • Phase III Randomized Trial | N = 91 | 82/100 | PMID 33395210 ↗ |
Tedizolid Phosphate Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $445.4998/unit (~$13364.99/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $453.25 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 9 Anonymous DotMD Community Micro-Logs | $185.00 / mo | View logs ↓ |
Tedizolid Phosphate Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Tedizolid Phosphate RxNorm Concept ID | RXN-67919040-3223 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $445.4998 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $453.25 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $185.00 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 94.00% Worth It (9 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Tedizolid Phosphate Patient Community, Cohort Filters & Dosage Logs
Evidence synthesis for Tedizolid Phosphate: FDA labeling (2026-07-01, NDC 67919-040), CYP/interaction screening, and public pharmacy acquisition costs.
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