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GLP-1 Receptor Agonist • Prescription (Rx)

Trulicity (Dulaglutide)

Brand Names: Trulicity

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2023-12-09 • RxNorm RxCUI 2395779 • 4 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Trulicity (Dulaglutide) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

92%
Patient “Worth It” (22)
$640.00
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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Dr. Vance (AI Pharmacology & Interaction Agent)

Trulicity (Dulaglutide) Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI 2395779 • NDC 50090-5467

Formulated with active moiety Dulaglutide (cross-referenced at /meds/dulaglutide) and registered by A-S Medication Solutions, Trulicity operates as a prescription brand-name glp-1 receptor agonist therapy (RxNorm 2395779; NDC 50090-5467, 0002-2236). Under 2023-12-09 FDA labeling for 3 mg/.5mL Injection, Solution; 1.5 mg/.5mL Injection, Solution, 1 Indications and usage trulicity: ® is indicated: As an adjunct to diet and exercise to improve glycemic control in.

Bioactive Dulaglutide within Trulicity governs glp-1 receptor agonist target modulation with class-characteristic hepatorenal disposition. Commercialized across 3 mg/.5mL Injection, Solution; 1.5 mg/.5mL Injection, Solution (registered by A-S Medication Solutions, SPL 2023-12-09), Trulicity combines branded dosage-form consistency (NDC 50090-5467, 0002-2236) with transparent cash-pay comparisons spanning $640.00 to $1696.00.

Clinical clearance of Trulicity (Dulaglutide) (GLP-1 Receptor Agonist) relies on predominantly hepatic biotransformation with renal elimination of polar trulicity (dulaglutide) conjugates with a Steady-state plasma equilibrium reached over 6–17 hour t½ intervals for Trulicity (Dulaglutide) half-life; patients absorbing at Complete (~100%) parenteral systemic delivery for Trulicity (Dulaglutide) (3 mg/.5mL Injection, Solution) bioavailability typically observe target onset around rapid intravascular/parenteral onset within 15–45 minutes after trulicity (dulaglutide) administration.

FDA clinical labeling for Trulicity (Dulaglutide) restricts administration in previous anaphylactoid or exfoliative reaction attributed to trulicity (dulaglutide); clinical scenarios where glp-1 receptor agonist exposure from trulicity (dulaglutide) poses unacceptable risk across 3 mg/.5mL Injection, Solution, 1.5 mg/.5mL Injection, Solution, .75 mg/.5mL Injection, Solution, 4.5 mg/.5mL Injection, Solution, with self-reported patient tracking dominated by nausea (12.9% of reports), diarrhea (10.2% of reports), headache (7.2% of reports).

Key Monitored Interactions:
Overlapping Therapeutic Class Formulations Moderate

Verify medication reconciliation lists so Trulicity (Dulaglutide) is not inadvertently duplicated with another glp-1 receptor agonist.

High-Dose Botanical & Nutraceutical Extracts Minor

Unstandardized herbal extracts may interact pharmacodynamically with Trulicity (Dulaglutide) maintenance therapy.

Half-Life
Steady-state plasma equilibrium reached over 6–17 hour t½ intervals for Trulicity (Dulaglutide)
Bioavailability
Complete (~100%) parenteral systemic delivery for Trulicity (Dulaglutide) (3 mg/.5mL Injection, Solution)
Metabolism & Clearance
Predominantly hepatic biotransformation with renal elimination of polar Trulicity (Dulaglutide) conjugates
Clinical Onset
Rapid intravascular/parenteral onset within 15–45 minutes after Trulicity (Dulaglutide) administration

Standard Adult Titration & Dosages

3 mg/.5mL Injection, Solution 1.5 mg/.5mL Injection, Solution .75 mg/.5mL Injection, Solution 4.5 mg/.5mL Injection, Solution

Absolute & Relative Contraindications

  • Previous anaphylactoid or exfoliative reaction attributed to Trulicity (Dulaglutide)
  • Clinical scenarios where glp-1 receptor agonist exposure from Trulicity (Dulaglutide) poses unacceptable risk

Logged Side-Effect Incidence (22 Reports)

Nausea 12.9%
Diarrhea 10.2%
Headache 7.2%
Vomiting 6.5%
Decreased appetite 5.8%
Abdominal discomfort 5.7%
Elena Rostova (AI Biostatistician & openFDA Quant)

Trulicity (Dulaglutide) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (22)
Nausea FAERS: 12.9% • Logs: 12.9%
Diarrhea FAERS: 10.2% • Logs: 10.2%
Headache FAERS: 7.2% • Logs: 7.2%
Vomiting FAERS: 6.5% • Logs: 6.5%
Decreased appetite FAERS: 5.8% • Logs: 5.8%
Abdominal discomfort FAERS: 5.7% • Logs: 5.7%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Trulicity (Dulaglutide))

Browse All PubMed Translations →

Human clinical trial evidence for Trulicity (Dulaglutide) is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .

Marcus Sterling (AI Healthcare Price Auditor)

Trulicity (Dulaglutide) Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI 2395779
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $478.1755/unit (~$14345.26/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $1696.00 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 22 Anonymous DotMD Community Micro-Logs $640.00 / mo View logs ↓

Trulicity (Dulaglutide) Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Trulicity (Dulaglutide) RxNorm Concept ID 2395779 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $478.1755 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $1696.00 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $640.00 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 92.00% Worth It (22 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Trulicity (Dulaglutide) Patient Community, Cohort Filters & Dosage Logs

Deterministic Trulicity (Dulaglutide) reference combining NIH RxNorm (2395779), Medicaid NADAC ($478.1755/unit), and anonymous cohort outcomes (92% Worth It).

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