Tuberculin Purified Protein Derivative
Brand Names: Tubersol, Aplisol, Tuberculinum
Methodology & AI Transparency ⓘ
Tuberculin Purified Protein Derivative Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Indications and usage tubersol: Tuberculin Purified Protein Derivative (Mantoux), is indicated to aid diagnosis of tuberculosis infection (TB) in persons at increased risk of developing active disease.
- 2 Real-world patient consensus: 89% patient "Worth It" rating across 20 anonymous logs for Tuberculin Purified Protein Derivative (RxNorm 313532).
- 3 Typical cash cost range: 30-day cash pricing ranges from $121.09 discount cash to $296.67 walk-in retail (NADAC $2.7800/unit).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Tuberculin Purified Protein Derivative: cutaneous rash (4.5%), pruritus (4.8%), application-site irritation (7.3%).
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Tuberculin Purified Protein Derivative Mechanism, CYP450 Pathways & DailyMed Monograph
Indications and usage tubersol: Tuberculin Purified Protein Derivative (Mantoux), is indicated to aid diagnosis of tuberculosis infection (TB) in persons at increased risk of developing active disease. The Centers for Disease Control and Prevention (CDC) have published guidelines regarding populations that would benefit from tuberculin skin testing (TST). Current recommendations can be accessed at: http://www.cdc.gov/tb/publications/factsheets/testing.htm. Previous BCG vaccination is not a contraindication to tuberculin testing.
Mechanism of Action The sensitization following infection with mycobacteria occurs primarily in the regional lymph nodes. Small lymphocytes (T lymphocytes) proliferate in response to the antigenic stimulus to give rise to specifically sensitized lymphocytes. After 3-8 weeks, these lymphocytes enter the blood stream and circulate for years. (6) Subsequent restimulation of these sensitized lymphocytes with the same or a similar antigen, such as the intradermal injection of TUBERSOL, evokes a local reaction mediated by these cells.
Systemic exposure to Tuberculin Purified Protein Derivative reflects Complete (~100%) parenteral systemic delivery for Tuberculin Purified Protein Derivative (5 [iU]/.1mL Injection, Solution) absorption kinetics and phase i/ii hepatic conjugation of tuberculin purified protein derivative coupled with glomerular and tubular renal excretion, sustaining receptor engagement across a Approximately 3–7 hours terminal plasma half-life for Tuberculin Purified Protein Derivative half-life window (rapid intravascular/parenteral onset within 15–45 minutes after tuberculin purified protein derivative administration response profile).
Dosing protocols (5 [iU]/.1mL Injection, Solution or 8 [hp_X]/1 Pellet or 15 [hp_C]/15[hp_C] Pellet or 30 [hp_C]/30[hp_C] Pellet or 5 [iU]/.1mL Injection) balance efficacy (89.00% patient satisfaction across 20 logs) against application-site erythema (7.9% of reports), application-site irritation (7.3% of reports), mild local dryness (6.5% of reports), with strict avoidance in prior anaphylaxis, angioedema, or severe hypersensitivity to tuberculin purified protein derivative or tuberculin purified protein derivative excipients; co-administration with prohibited interacting drugs or decompensated organ failure per 2026-05-01 tuberculin purified protein derivative spl.
Avoid overlapping skin test antigen prescriptions alongside Tuberculin Purified Protein Derivative to prevent cumulative receptor toxicity.
Alcohol or high-fat meal timing can shift absorption rate and orthostatic tolerance during Tuberculin Purified Protein Derivative dosing.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Prior anaphylaxis, angioedema, or severe hypersensitivity to Tuberculin Purified Protein Derivative or Tuberculin Purified Protein Derivative excipients
- Co-administration with prohibited interacting drugs or decompensated organ failure per 2026-05-01 Tuberculin Purified Protein Derivative SPL
Logged Side-Effect Incidence (20 Reports)
Tuberculin Purified Protein Derivative Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Tuberculin Purified Protein Derivative)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Accuracy of ESAT6-CFP10 skin test compared with tuberculin skin test in a healthy: What a 1,564-Participant Study Found The diagnostic performance of the EC skin test was similar to that of the T-SPOT test in the healthy population and was unaffected by BCG vaccination. BMC infectious diseases • 2024-12-30 • Phase III Randomized Trial | N = 1,564 | 96/100 | PMID 39736611 ↗ |
| Can This Approach Help? Inside the Latest Research on High accuracy of recombinant fusion protein early secretory antigenic target The diagnostic performance of the ECST was close to the T-SPOT.TB assay in the detection of TB infection and indicated good potential for clinical application in common scenarios. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases • 2023-01-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 36400376 ↗ |
Tuberculin Purified Protein Derivative Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $2.7800/unit (~$83.40/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $296.67 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 20 Anonymous DotMD Community Micro-Logs | $121.09 / mo | View logs ↓ |
Tuberculin Purified Protein Derivative Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Tuberculin Purified Protein Derivative RxNorm Concept ID | 313532 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $2.7800 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $296.67 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $121.09 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 89.00% Worth It (20 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Tuberculin Purified Protein Derivative Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Tuberculin Purified Protein Derivative integrating DailyMed SPL (2026-05-01), CMS NADAC ($2.7800/unit), and 20 Zero-PHI patient logs.
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Filter Tuberculin Purified Protein Derivative community threads and patient logs by age, biological sex, dosage, and treatment duration.