Vigabatrin
Brand Names: Sabril, Vigafyde, Vigadrone
Methodology & AI Transparency ⓘ
Vigabatrin Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Vigabatrin tablets are indicated for the treatment of: Refractory Complex Partial Seizures as adjunctive therapy in patients 2 years of age and older who have responded inadequately to several alternative treatments; Vigabatrin tablets are not indicated as a first line agent ( 1.1 ) Infantile Spasms - monotherapy in infants 1 month to 2 years of age for whom the potential benefits outweigh the potential risk of vision loss ( 1.2 ) 1.1 Refractory Complex Partial Seizures (CPS) Vigabatrin tablets are indicated as adjunctive therapy for adults and pediatric patients 2 years of age and older with refractory complex.
- 2 Real-world patient consensus: Zero-PHI community consensus: 85% favorable across 18 logged regimens (Sabril, Vigafyde).
- 3 Typical cash cost range: 30-day cash pricing ranges from $145.80 discount cash to $357.21 walk-in retail (NADAC $3.3900/unit).
- 4 Top reported side effects / signs: Most commonly reported Vigabatrin tolerability events: dizziness (7.4%), fatigue (7.2%), somnolence (8.1%).
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Vigabatrin Mechanism, CYP450 Pathways & DailyMed Monograph
Vigabatrin tablets are indicated for the treatment of: Refractory Complex Partial Seizures as adjunctive therapy in patients 2 years of age and older who have responded inadequately to several alternative treatments; Vigabatrin tablets are not indicated as a first line agent ( 1.1 ) Infantile Spasms - monotherapy in infants 1 month to 2 years of age for whom the potential benefits outweigh the potential risk of vision loss ( 1.2 ) 1.1 Refractory Complex Partial Seizures (CPS) Vigabatrin tablets are indicated as adjunctive therapy for adults and pediatric patients 2 years of age and older with refractory complex.
12.1 Mechanism of Action The precise mechanism of vigabatrin’s anti-seizure effect is unknown, but it is believed to be the result of its action as an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the metabolism of the inhibitory neurotransmitter GABA. This action results in increased levels of GABA in the central nervous system. No direct correlation between plasma concentration and efficacy has been established. The duration of drug effect is presumed to be dependent on the rate of enzyme re-synthesis rather than on the rate of elimination of the drug from the systemic circulation.
With Elimination kinetics span 8 to 12 hours per Vigabatrin clinical pharmacology residence kinetics and Consistent 56%–68% gastrointestinal absorption profile for Vigabatrin bioavailability, Vigabatrin undergoes systemic clearance of vigabatrin integrates hepatic phase ii conjugation with renal filtration and establishes therapeutic activity over cmax attained 2–5 hours post-administration of vigabatrin.
Standard adult regimens span 50 mg/mL For Solution, 500 mg/1 Tablet, Film Coated, 500 mg/1 Powder, for Solution, 500 mg/1 For Solution, 50 mg/mL Powder, for Solution. Prescribers screen specifically against confirmed ige-mediated allergy or cutaneous reaction to vigabatrin (vigabatrin) components; uncompensated hepatic or renal insufficiency incompatible with vigabatrin (50 mg/ml for solution) clearance, while community micro-logs most frequently note nausea (8.5% of reports), somnolence (8.1% of reports), dizziness (7.4% of reports).
Rifampin or anticonvulsant inducers can diminish Vigabatrin systemic exposure and clinical response.
Reconcile eGFR-adjusted medications before escalating Vigabatrin in polypharmacy regimens.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Confirmed IgE-mediated allergy or cutaneous reaction to Vigabatrin (Vigabatrin) components
- Uncompensated hepatic or renal insufficiency incompatible with Vigabatrin (50 mg/mL For Solution) clearance
Logged Side-Effect Incidence (18 Reports)
Vigabatrin Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Vigabatrin)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| Can This Approach Help? Inside the Latest Research on Modified Atkins diet versus topiramate in young children with epileptic spasms MAD proved to be more effective than Topiramate in managing epileptic spasms refractory to first-line treatment. Seizure • 2025-09-15 • Phase III Randomized Trial | N = 80 | 82/100 | PMID 40840039 ↗ |
Vigabatrin Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $3.3900/unit (~$101.70/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $357.21 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 18 Anonymous DotMD Community Micro-Logs | $145.80 / mo | View logs ↓ |
Vigabatrin Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Vigabatrin RxNorm Concept ID | 199521 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $3.3900 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $357.21 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $145.80 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 85.00% Worth It (18 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Vigabatrin Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Vigabatrin integrating DailyMed SPL (2020-03-17), CMS NADAC ($3.3900/unit), and 18 Zero-PHI patient logs.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Filter Vigabatrin community threads and patient logs by age, biological sex, dosage, and treatment duration.