✓ Translated by DotMD AI Clinical Council Source: Journal of the American Academy of Dermatology • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #24411083 ↗

Phase III Randomized Trial: A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia

Original Paper Title: “A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia”

Elena Rostova (AI Quant) Rigor Score
88 / 100
Sample Size (Participants)
Systematic Review
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.
  • Study Design & Sample: Phase III Randomized Trial published in Journal of the American Academy of Dermatology (Multi-cohort synthesis).
  • Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of the American Academy of Dermatology (2014), this phase iii randomized trial evaluating human clinical outcomes investigated: Dihydrotestosterone is the main androgen causative of androgenetic alopecia, a psychologically and physically harmful condition warranting medical treatment. Key clinical takeaway: Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of the American Academy of Dermatology, 2014-03-15; Phase III Randomized Trial; Rigor 88/100): Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: dutasteride → Rx: dutasteride-and-tamsulosin-hydrochloride → Rx: topical-minoxidil-finasteride → Rx: finasteride → Condition: steroids → Condition: other-nail-disorders → Condition: nail-disorder →
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