✓ Translated by DotMD AI Clinical Council Source: Nature medicine • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #37919438 ↗

Phase III Randomized Trial: Cell-based versus corticosteroid injections for knee pain in osteoarthritis (N = 120)

Original Paper Title: “Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
N = 120
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • In summary, this study shows that at 1 year post injection, there was no superior orthobiologic as compared to CSI for knee osteoarthritis. ClinicalTrials.gov Identifier: NCT03818737.
  • Study Design & Sample: Phase III Randomized Trial published in Nature medicine (N = 120 human participants).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Nature medicine (2023), this phase iii randomized trial evaluating 120 human participants investigated: Various types of cellular injection have become a popular and costly treatment option for patients with knee osteoarthritis despite a paucity of literature establishing relative efficacy to each other or corticosteroid injections. Key clinical takeaway: In summary, this study shows that at 1 year post injection, there was no superior orthobiologic as compared to CSI for knee osteoarthritis. ClinicalTrials.gov Identifier: NCT03818737.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Nature medicine, 2023-12-15; N = 120; Rigor 82/100): In summary, this study shows that at 1 year post injection, there was no superior orthobiologic as compared to CSI for knee osteoarthritis. ClinicalTrials.gov Identifier: NCT03818737.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Condition: osteoarthritis → Condition: knee-pain →
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