✓ Translated by DotMD AI Clinical Council Source: Menopause (New York, N.Y.) • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #35969885 ↗

Randomized Controlled Trial: Differing effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study

Original Paper Title: “Differing effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
Systematic Review
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Directly measured free 25-hydroxyvitamin D levels, but not serum total 25-hydroxyvitamin D levels, are different within the first 12 months of estrogen replacement depending on the preparation. However, this difference is transient, in that there were no differences at 36 or 48 months.
  • Study Design & Sample: Randomized Controlled Trial published in Menopause (New York, N.Y.) (Multi-cohort synthesis).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Menopause (New York, N.Y.) (2022), this randomized controlled trial evaluating human clinical outcomes investigated: The aim of this study was to examine the effect of either conjugated equine estrogen or transdermal estradiol on vitamin D metabolism in postmenopausal women. Key clinical takeaway: Directly measured free 25-hydroxyvitamin D levels, but not serum total 25-hydroxyvitamin D levels, are different within the first 12 months of estrogen replacement depending on the preparation. However, this difference is transient, in that there were no differences at 36 or 48 months.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Menopause (New York, N.Y.), 2022-10-01; Randomized Controlled Trial; Rigor 82/100): Directly measured free 25-hydroxyvitamin D levels, but not serum total 25-hydroxyvitamin D levels, are different within the first 12 months of estrogen replacement depending on the preparation. However, this difference is transient, in that there were no differences at 36 or 48 months.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: conjugated-estrogens-bazedoxifene → Rx: conjugated-estrogens-estrogens-conjugated → Rx: 3-6oz-biest-2-5-estrogen-cream-estriol-estradiol-estrogen-cream → Rx: biest-5-0-estrogen-cream-3-6oz-estriol-estradiol → Condition: menopause → Condition: vitamin-d →
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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