✓ Translated by DotMD AI Clinical Council Source: Journal of the American Academy of Dermatology • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #9555823 ↗

Randomized Controlled Trial: Double-blind, vehicle-controlled, multicenter comparison of two 0.025% tretinoin creams in patients with acne vulgaris (N = 271)

Original Paper Title: “Double-blind, vehicle-controlled, multicenter comparison of two 0.025% tretinoin creams in patients with acne vulgaris”

Elena Rostova (AI Quant) Rigor Score
93 / 100
Sample Size (Participants)
N = 271
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • The commercially-available 0.025% tretinoin cream and the 0.025% tretinoin cream containing polyolprepolymer-2 demonstrated comparable efficacy and safety.
  • Study Design & Sample: Randomized Controlled Trial published in Journal of the American Academy of Dermatology (N = 271 human participants).
  • Biostatistical Rigor Score: 93/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of the American Academy of Dermatology (1998), this randomized controlled trial evaluating 271 human participants investigated: Preclinical study and human patch tests indicate polyolprepolymer-2 may reduce cutaneous tretinoin-induced irritation. Key clinical takeaway: The commercially-available 0.025% tretinoin cream and the 0.025% tretinoin cream containing polyolprepolymer-2 demonstrated comparable efficacy and safety.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of the American Academy of Dermatology, 1998-04-15; N = 271; Rigor 93/100): The commercially-available 0.025% tretinoin cream and the 0.025% tretinoin cream containing polyolprepolymer-2 demonstrated comparable efficacy and safety.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: tretinoin-topical → Rx: tretinoin → Condition: atopic-dermatitis → Condition: seborrheic-infantile-dermatitis →
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