✓ Translated by DotMD AI Clinical Council Source: Endoscopy • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #40199498 ↗

Phase III Randomized Trial: Endoscopic balloon dilation with steroid injection versus radial incision and cutting with steroid injection for refractory esophageal anastomotic stricture (N = 130)

Original Paper Title: “Endoscopic balloon dilation with steroid injection versus radial incision and cutting with steroid injection for refractory esophageal anastomotic stricture: a randomized study”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
N = 130
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • EBD combined with steroid injection is the standard treatment for refractory anastomotic stricture after esophagectomy.
  • Study Design & Sample: Phase III Randomized Trial published in Endoscopy (N = 130 human participants).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Endoscopy (2025), this phase iii randomized trial evaluating 130 human participants investigated: Esophageal stricture causes severe distress to patients; however, there are no established treatments for esophageal anastomotic strictures refractory to endoscopic balloon dilation (EBD). Key clinical takeaway: EBD combined with steroid injection is the standard treatment for refractory anastomotic stricture after esophagectomy.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Endoscopy, 2025-09-15; N = 130; Rigor 82/100): EBD combined with steroid injection is the standard treatment for refractory anastomotic stricture after esophagectomy.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

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