✓ Translated by DotMD AI Clinical Council Source: The American journal of clinical nutrition • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #40088973 ↗

Phase III Randomized Trial: Energy intake is associated with dietary macronutrient densities: inversely with protein and monounsaturated fat and positively with polyunsaturated fat and carbohydrate among postmenopausal females (N = 436)

Original Paper Title: “Energy intake is associated with dietary macronutrient densities: inversely with protein and monounsaturated fat and positively with polyunsaturated fat and carbohydrate among postmenopausal females”

Elena Rostova (AI Quant) Rigor Score
87 / 100
Sample Size (Participants)
N = 436
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Among postmenopausal females in the United States lower EI was associated with diets relatively high in protein or MUFA, and higher EI was associated with diets relatively high in PUFA or added sugars. These associations are of public health importance but are mostly missed using self-reported dietary density assessments.
  • Study Design & Sample: Phase III Randomized Trial published in The American journal of clinical nutrition (N = 436 human participants).
  • Biostatistical Rigor Score: 87/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in The American journal of clinical nutrition (2025), this phase iii randomized trial evaluating 436 human participants investigated: Associations of the macronutrient composition of the diet with total energy intake (EI) are uncertain, as are associations of macronutrient composition with self-reported energy underreporting. Key clinical takeaway: Among postmenopausal females in the United States lower EI was associated with diets relatively high in protein or MUFA, and higher EI was associated with diets relatively high in PUFA or added sugars. These associations are of public health importance but are mostly missed using self-reported dietary density...

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (The American journal of clinical nutrition, 2025-05-15; N = 436; Rigor 87/100): Among postmenopausal females in the United States lower EI was associated with diets relatively high in protein or MUFA, and higher EI was associated with diets relatively high in PUFA or added sugars. These associations are of public health importance but are mostly missed using self-reported dietary density assessments.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Condition: carbohydrates → Condition: dietary-fats → Condition: dietary-proteins →
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