✓ Translated by DotMD AI Clinical Council Source: Neuro-oncology • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #40048707 ↗

Phase III Randomized Trial: Gut microbiome modulates the outcome in primary central nervous system lymphoma patients undergoing chemotherapy: An ancillary study from the BLOCAGE trial (N = 52)

Original Paper Title: “Gut microbiome modulates the outcome in primary central nervous system lymphoma patients undergoing chemotherapy: An ancillary study from the BLOCAGE trial”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
N = 52
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Our findings suggest that gut microbiome communities modulate clinical outcomes in PCNSL patients undergoing standard treatment.
  • Study Design & Sample: Phase III Randomized Trial published in Neuro-oncology (N = 52 human participants).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Neuro-oncology (2025), this phase iii randomized trial evaluating 52 human participants investigated: Primary central nervous system lymphoma (PCNSL) treatment relies on a high-dose methotrexate-based chemotherapy (HD-MTX-based CT) regimen; however, whether there is a specific microbiota composition association with treatment response and clinical outcomes remains incompletely understood. Key clinical takeaway: Our findings suggest that gut microbiome communities modulate clinical outcomes in PCNSL patients undergoing standard treatment.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Neuro-oncology, 2025-09-17; N = 52; Rigor 82/100): Our findings suggest that gut microbiome communities modulate clinical outcomes in PCNSL patients undergoing standard treatment.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: methotrexate → Condition: lymphoma → Condition: sarcoma-myeloid → Condition: nodular-sclerosis →
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