✓ Translated by DotMD AI Clinical Council Source: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology • Phase III Randomized Trial

Verify Primary Source: NIH PubMed PMID #41966354 ↗

Phase III Randomized Trial: Impact of vitamin D status and supplementation on exploratory inflammatory biomarkers in preschoolers with asthma (N = 198)

Original Paper Title: “Impact of vitamin D status and supplementation on exploratory inflammatory biomarkers in preschoolers with asthma”

Elena Rostova (AI Quant) Rigor Score

88 / 100

Sample Size (Participants)

N = 198

Evidence Classification

Phase III Randomized Trial

Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways

In preschoolers with virus-induced asthma, serum 25(OH)D was inversely associated with neutrophils, and vitamin D supplementation significantly reduced CRP and neutrophils over time, suggesting modulation of neutrophilic inflammation.
Study Design & Sample: Phase III Randomized Trial published in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (N = 198 human participants).
Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (2026), this phase iii randomized trial evaluating 198 human participants investigated: Vitamin D supplementation may improve asthma by modulating inflammation, but its effects in preschoolers with virus-induced asthma remain underexplored. Key clinical takeaway: In preschoolers with virus-induced asthma, serum 25(OH)D was inversely associated with neutrophils, and vitamin D supplementation significantly reduced CRP and neutrophils over time, suggesting modulation of neutrophilic inflammation.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2026-07-15; N = 198; Rigor 88/100): In preschoolers with virus-induced asthma, serum 25(OH)D was inversely associated with neutrophils, and vitamin D supplementation significantly reduced CRP and neutrophils over time, suggesting modulation of neutrophilic inflammation.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: vitamin-mineral-supplement → Rx: iron-folic-acid-vitamin-mineral-supplement → Condition: dietary-supplements → Condition: vitamin-d →

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