✓ Translated by DotMD AI Clinical Council Source: Journal of child and adolescent psychopharmacology • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #18759650 ↗

Randomized Controlled Trial: Maintenance study for adolescent depression (N = 13)

Original Paper Title: “Maintenance study for adolescent depression”

Elena Rostova (AI Quant) Rigor Score
88 / 100
Sample Size (Participants)
N = 13
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • This is the first study to examine the outcome to maintenance treatment for adolescents with major depression. Although the sample size was small, the findings suggest a possible benefit of maintenance treatment with sertraline over placebo. A larger clinical trial with adequate power is required to confirm or disconfirm these findings.
  • Study Design & Sample: Randomized Controlled Trial published in Journal of child and adolescent psychopharmacology (N = 13 human participants).
  • Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of child and adolescent psychopharmacology (2008), this randomized controlled trial evaluating 13 human participants investigated: Although recent studies and meta-analyses confirm the efficacy of antidepressants in the acute phase of treatment for adolescent depression, there are few data available to allow assessment of the value of continued use of antidepressants in depressed adolescents after acute response. Key clinical takeaway: This is the first study to examine the outcome to maintenance treatment for adolescents with major depression. Although the sample size was small, the findings suggest a possible benefit of maintenance treatment...

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of child and adolescent psychopharmacology, 2008-08-15; N = 13; Rigor 88/100): This is the first study to examine the outcome to maintenance treatment for adolescents with major depression. Although the sample size was small, the findings suggest a possible benefit of maintenance treatment with sertraline over placebo. A larger clinical trial with adequate power is required to confirm or disconfirm these findings.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: sertraline-hcl → Rx: sertraline-hydrochloride → Condition: depression → Condition: bipolar-disorder-current-episode-manic-without-psychotic-features-moderate → Condition: bipolar-disorder-current-episode-manic-severe-with-psychotic-features →
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