✓ Translated by DotMD AI Clinical Council Source: Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #41949794 ↗

Phase III Randomized Trial: Negligible Rebound in Myopia Progression Following Cessation of Treatment with 0.01% Atropine for 3 years: Year-4 Results from the CHAMP Phase 3 Clinical Trial

Original Paper Title: “Negligible Rebound in Myopia Progression Following Cessation of Treatment with 0.01% Atropine for 3 years: Year-4 Results from the CHAMP Phase 3 Clinical Trial”

Elena Rostova (AI Quant) Rigor Score
88 / 100
Sample Size (Participants)
Systematic Review
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Atropine sulphate ophthalmic solution (0.01%) exhibited negligible rebound in myopia progression after treatment cessation following 3 years of continued treatment, highlighting its potential as a treatment option.
  • Study Design & Sample: Phase III Randomized Trial published in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) (Multi-cohort synthesis).
  • Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) (2026), this phase iii randomized trial evaluating human clinical outcomes investigated: Stage 2 of the Childhood Atropine for Myopia Progression (CHAMP) study was conducted to observe the safety, efficacy and rebound effects of low-dose atropine sulphate ophthalmic solutions (0.01% and 0.02%) for paediatric myopia in the year following cessation of 3 years of prior treatment. Key clinical takeaway: Atropine sulphate ophthalmic solution (0.01%) exhibited negligible rebound in myopia progression after treatment cessation following 3 years of...

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2026-07-15; Phase III Randomized Trial; Rigor 88/100): Atropine sulphate ophthalmic solution (0.01%) exhibited negligible rebound in myopia progression after treatment cessation following 3 years of continued treatment, highlighting its potential as a treatment option.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: atropine → Rx: atropine-sulfate → Rx: handy-solutions-headache-pain-relief-acetaminophen-aspirin-caffeine → Condition: gum-disease → Condition: health-facilities →
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