✓ Translated by DotMD AI Clinical Council Source: Sleep medicine • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #31132578 ↗

Randomized Controlled Trial: Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder (N = 170)

Original Paper Title: “Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
N = 170
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Individuals with DSWPD who have more delayed sleep and a greater phase angle also have more irregular sleep. This suggests that it is not delayed sleep timing per se that drives poor functional outcomes in DSWPD, but rather the timing of sleep relative to circadian phase and resultant irregular sleep patterns.
  • Study Design & Sample: Randomized Controlled Trial published in Sleep medicine (N = 170 human participants).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Sleep medicine (2019), this randomized controlled trial evaluating 170 human participants investigated: In healthy populations, irregular sleep patterns are associated with delayed sleep and poor functional/mood outcomes. Key clinical takeaway: Individuals with DSWPD who have more delayed sleep and a greater phase angle also have more irregular sleep. This suggests that it is not delayed sleep timing per se that drives poor functional outcomes in DSWPD, but rather the timing of sleep relative to circadian phase and resultant irregular sleep patterns.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Sleep medicine, 2019-06-15; N = 170; Rigor 82/100): Individuals with DSWPD who have more delayed sleep and a greater phase angle also have more irregular sleep. This suggests that it is not delayed sleep timing per se that drives poor functional outcomes in DSWPD, but rather the timing of sleep relative to circadian phase and resultant irregular sleep patterns.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: biological-complex-i-variolinum → Condition: mood-disorders → Condition: sleep-disorders →
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