✓ Translated by DotMD AI Clinical Council Source: The American journal on addictions • Randomized Controlled Trial
Verify Primary Source: NIH PubMed PMID #16867922 ↗

Randomized Controlled Trial: Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohort

Original Paper Title: “Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohort”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
Systematic Review
Evidence Classification
Randomized Controlled Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater fun.
  • Study Design & Sample: Randomized Controlled Trial published in The American journal on addictions (Multi-cohort synthesis).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in The American journal on addictions (2006), this randomized controlled trial evaluating human clinical outcomes investigated: The demographics and clinical features were compared between those with (29.4%) and without concurrent substance use disorder (SUD) in 2541 outpatients with major depression (MDD) enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Key clinical takeaway: Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more...

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (The American journal on addictions, 2006-01-15; Randomized Controlled Trial; Rigor 82/100): Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater fun.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Randomized Controlled Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: bupropion-xl → Rx: bupropion-hydrochloride → Rx: citalopram-hydrobromide → Rx: citalopram → Condition: suicide → Condition: manic-episode → Condition: manic-episode-in-partial-remission →
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