✓ Translated by DotMD AI Clinical Council Source: Journal of the American College of Cardiology • Phase III Randomized Trial

Verify Primary Source: NIH PubMed PMID #37380301 ↗

Phase III Randomized Trial: Treatment of Idiopathic Recurrent Pericarditis With Goflikicept: Phase II/III Study Results (N = 22)

Original Paper Title: “Treatment of Idiopathic Recurrent Pericarditis With Goflikicept: Phase II/III Study Results”

Elena Rostova (AI Quant) Rigor Score

88 / 100

Sample Size (Participants)

N = 22

Evidence Classification

Phase III Randomized Trial

Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways

Treatment with goflikicept prevented recurrences and maintained IRP remission with a favorable risk-benefit ratio. Goflikicept reduced the risk of recurrence compared with placebo. (Study to Evaluate the Efficacy and Safety of RPH-104 Treatment in Patients With Idiopathic Recurrent Pericarditis; NCT04692766).
Study Design & Sample: Phase III Randomized Trial published in Journal of the American College of Cardiology (N = 22 human participants).
Biostatistical Rigor Score: 88/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Journal of the American College of Cardiology (2023), this phase iii randomized trial evaluating 22 human participants investigated: Idiopathic recurrent pericarditis (IRP) is a rare autoinflammatory disease. Key clinical takeaway: Treatment with goflikicept prevented recurrences and maintained IRP remission with a favorable risk-benefit ratio. Goflikicept reduced the risk of recurrence compared with placebo. (Study to Evaluate the Efficacy and Safety of RPH-104 Treatment in Patients With Idiopathic Recurrent Pericarditis; NCT04692766).

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Journal of the American College of Cardiology, 2023-07-04; N = 22; Rigor 88/100): Treatment with goflikicept prevented recurrences and maintained IRP remission with a favorable risk-benefit ratio. Goflikicept reduced the risk of recurrence compared with placebo. (Study to Evaluate the Efficacy and Safety of RPH-104 Treatment in Patients With Idiopathic Recurrent Pericarditis; NCT04692766).

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

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