Adaptogens & Stress Resilience • NIH Office of Dietary Supplements (DSLD)

Ashwagandha Root Extract (Withania somnifera)

Active Constituents: Ashwagandha, Pullulan

Climate Change (F40.2) Mental Disorders (F48.9) Radiation Emergencies (F43.7) Tornadoes (F43.5)

Audited by the DotMD AI Specialist Council • NIH DSLD #323200 • 4 Linked .gov / PubMed Citations

Methodology & AI Transparency ⓘ

Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.

At a Glance • Plain-English Clinical Summary

Ashwagandha Root Extract (Withania somnifera) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

90%

Patient “Worth It” (12)

$21

Lowest Cash / Mo

1 What it does: Standardized withanolide adaptogen studied in randomized trials for blunting elevated morning serum cortisol, perceived stress scores, and sleep-onset latency.
2 Real-world patient consensus: 90% patient "Worth It" rating across 12 anonymous logs for Ashwagandha Root Extract (Withania somnifera) (NIH DSLD #323200).
3 Typical cash cost range: Typical 30-day outlay for Ashwagandha Root Extract (Withania somnifera): $21.00 (300 mg standardized root extract (5% withanolides) twice daily).
4 Top reported side effects / signs: Medication safety check: review Levothyroxine & Antithyroid Medications co-administration (Moderate).

Pharmacology & Clinical Trial Dosing

How Ashwagandha Root Extract (Withania somnifera) Works & Standard Studied Dosages

Standardized withanolide adaptogen studied in randomized trials for blunting elevated morning serum cortisol, perceived stress scores, and sleep-onset latency.

Attenuates hypothalamic-pituitary-adrenal (HPA) axis cortisol hypersecretion and exerts GABA-A mimetic modulation across limbic stress circuits.

Typical Human Study Regimens

300 mg standardized root extract (5% withanolides) twice daily 600 mg once daily with dinner

View Official NIH Office of Dietary Supplements Fact Sheet ↗

Dr. Vance (AI PharmD Clinical Pharmacologist)

Ashwagandha Root Extract (Withania somnifera) Prescription Drug Interactions & Side Effects

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Levothyroxine & Antithyroid Medications Moderate

May stimulate endogenous T4/T3 secretion; monitor TSH 6–8 weeks after starting.

Benzodiazepines, Zolpidem & CNS Sedatives Moderate

Additive GABAergic sedation and daytime drowsiness.

Reported Side Effects & Tolerability Notes

Mild drowsiness Stomach upset on empty stomach Rare idiosyncratic hepatic transaminase elevation (discontinue if jaundice/pruritus)

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Ashwagandha Root Extract (Withania somnifera))

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Study & Plain-English Finding	Sample (N)	Rigor	Primary Source
Can Ashwagandha Really Calm Daily Stress Without Leaving You Groggy? Vitality Works Inc. of Albuquerque, New Mexico, is recalling one lot (lot number 2025-26227) of 365 Whole Foods Market Standardized + Full Spectrum Blend Ashwagandha Capsules 120 count because it has the potential to be contaminated with Salmonella, an organis FDA Drug Recalls • 2026-10-30 • FDA Recall	Multi-cohort	95/100	PMID FDA_RECALLS-942024156 ↗

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