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★ "What Worked For Me" Outcome Report @SlowTitrate_OR • 45-59F • UC-II 40 mg + curcuminoids 2 • Week 16

▲ 36 Helpful • 2 Peer Replies

UC-II 40 mg + curcumin phytosome + omega-3 (16 wks update): Hand and knee OA, age 58 — what worked for others here?

Hand and knee OA, age 58. I was skeptical about supplements, so I tracked them like a trial. I started with a 4-week baseline using diclofenac gel only, then added undenatured type II collagen (UC-II) 40 mg every morning. At week 6, I added curcumin phytosome providing about 200 mg curcuminoids per day, split in two doses with meals. I also took omega-3 at 1 g EPA+DHA daily. Results: my pain score fell from 6/10 to about 4/10 by week 16, and I used gel on about half as many days. I cannot say which supplement helped most, and placebo effect is possible. I had ALT/AST checked at baseline and week 12 and both were normal. Because my CBC and bleeding history matter with fish oil and curcumin, my clinician approved the stack first. It is not a replacement for exercise or a prescribed plan.

⚕ Pinned FDA / NIH / PubMed Clinical Context • Nattapong Srisai — Literature & Label Auditor

A PubMed-indexed randomized trial (Lugo 2016) compared UC-II 40 mg daily with glucosamine plus chondroitin and placebo over 180 days in knee OA, with improvements in WOMAC scores reported for UC-II. Evidence for curcumin phytosome and omega-3 in OA is mixed, and NIH NCCIH describes rare turmeric-associated liver injury.

Connected Clinical Guides: Condition: Osteoarthritis Condition: Rheumatoid Arthritis Rx: Meloxicam Rx: Celecoxib Supplement: Curcumin Turmeric Supplement: Glucosamine Chondroitin

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Verified Peer Replies (2)

@QuietPulse_CO • Verified Cohort Member • Week 24

Adding one product at a time, as you did, is the right approach for judging effect. Keep a simple log of pain score, rescue doses and side effects. Note that undenatured collagen (40 mg) and hydrolyzed collagen peptides (often 5-10 g) are different products with different trial evidence.

@LabDetective_OR • Age 60+ • Week 12

I tried the same with collagen peptides at 10 g daily for 12 weeks and noticed only a small change in knee stiffness. I stopped fish oil because I take apixaban. My doctor said to avoid stacking supplements that might affect bleeding.