Our Agents Can’t Be Bought — Wired Straight Into the Government’s Own Medical Receipts

AI Clinical Research Agents & Primary-Registry Auditors

To eliminate medical ghostwriting and YMYL persona risk, every clinical monograph, drug price lookup, and supplement stoichiometry table on dotMD.com is synthesized and cross-audited by specialized Deterministic AI Clinical Research Agents (v4.2) bound directly to primary federal registries (NIH ODS, NIH DSLD v9, FDA DailyMed SPL, CMS NADAC) and NCBI PubMed randomized controlled trials.

Read Our 4-Tier Clinical Evidence & AI Governance Charter → Engineered & maintained by the dotMD Clinical Systems Architecture Team • audit@dotmd.com

dotMD-ClinSynth v4.2

ICD-10-CM & ADA/ACC-AHA Diagnostic Cutoff Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-ClinSynth v4.2 is the primary clinical synthesis agent responsible for mapping ICD-10-CM condition monographs, translating commercial lab portal bell-curve ranges into optimal physiological cutoffs, and generating 10-second appointment agendas.

Locked Mathematical & Stoichiometry Formulas:

 HOMA-IR Insulin Resistance Index = (Fasting Glucose [mg/dL] × Fasting Insulin [µIU/mL]) / 405 (Optimal < 1.5; Insulin Resistance ≥ 2.0)

Estimated Average Glucose (eAG mg/dL) = (28.7 × HbA1c [%]) − 46.7

2 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-PharmAudit v4.2

FDA DailyMed, RxNorm & NIH DSLD Stoichiometry Auditor

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-PharmAudit v4.2 is the adversarial pharmacokinetic and stoichiometry verification agent responsible for auditing every prescription monograph, supplement elemental weight calculation, and 24-hour pill clock schedule against primary federal XML registries.

Locked Mathematical & Stoichiometry Formulas:

 True Elemental mg = Label Compound Weight (mg) × (Atomic Mass of Element / Molecular Weight of Chelate) [e.g., Mg Bisglycinate = 14.10%]

CMS NADAC Retail Spread = ((Walk-In Chain Retail − (NADAC Unit Cost × 30)) / (NADAC Unit Cost × 30)) × 100

2 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-BioStat v4.2

NCBI PubMed Trial ARR, NNT & Biostatistical Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-BioStat v4.2 audits every clinical study breakdown and daily health news report on dotMD.com, converting sensationalized media percentages into transparent placebo-vs-drug baseline tables.

Locked Mathematical & Stoichiometry Formulas:

Absolute Risk Reduction (ARR) = |Control Event Rate (CER) − Experimental Event Rate (EER)| Number Needed to Treat (NNT) = 1 / ARR (rounded up to nearest whole patient over trial duration)

2 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-StoichBot v4.2

NIH DSLD v9 Elemental Label Math & TrueDose™ Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-StoichBot v4.2 powers the dotMD Supplement Label Decoder and the TrueDose™ 0–100 Bottle Trust Score, auditing commercial supplement labels against molecular weight constants and human fractional absorption studies.

Locked Mathematical & Stoichiometry Formulas:

 TrueDose™ Score (0–100) = Bioavailable Form (30) + RCT Dose Match (25) + 3rd-Party Purity (20) + Clean Excipients (15) + Label Honesty (10) − Fraud Penalties

True 30-Day Clinical Cost = (Human RCT Target Dose [mg] / True Elemental mg per Unit) × 30 × Price per Unit

2 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-Tolerability v4.2

openFDA FAERS Side-Effect Mitigation & PK Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-Tolerability v4.2 audits prescription side-effect profiles by separating true pharmacological adverse events from background placebo rates and identifying evidence-backed timing or formulation switches.

Locked Mathematical & Stoichiometry Formulas:

Net Drug-Attributable Side-Effect Rate = Active Arm Incidence (%) − Placebo Arm Incidence (%) Nocebo Burden Ratio = Mean Symptom Intensity on Blinded Placebo / Mean Symptom Intensity on Blinded Active Drug

1 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-PriceLedger v4.2

CMS Medicaid NADAC Wholesale Rx Price Auditor

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-PriceLedger v4.2 audits prescription pricing across dotMD.com, exposing the exact per-unit wholesale invoice price brick-and-mortar pharmacies pay wholesalers (CMS NADAC) so patients never overpay $50+ for a $5.40 generic.

Locked Mathematical & Stoichiometry Formulas:

30-Day Wholesale Acquisition Baseline = CMS NADAC Per-Unit Cost (USD) × 30 Tablets Patient Annual Cash Savings = 12 × (Chain Walk-In Retail Monthly Price − Verified Wholesale Cash Monthly Price)

2 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-ClaimAudit v4.2

CMS Part B Specialist CPT Volume & GreatDoc™ Auditor

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-ClaimAudit v4.2 powers the /doctors directory and GreatDoc™ scoring engine, ranking specialists by verified annual in-office procedure volume rather than paid directory sponsorships.

Locked Mathematical & Stoichiometry Formulas:

 GreatDoc™ Composite Score = 0.55 × (CMS State Specialty CPT Percentile) + 0.35 × (Bayesian-Weighted Patient Rating) + 0.10 × (Billing Transparency Index)

2 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-MyoKinetics v4.2

Neuromuscular, Electrolyte & GLUT4 Kinetics Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-MyoKinetics v4.2 synthesizes human clinical trials on skeletal muscle glucose disposal, nocturnal leg cramp physiology, and lean-mass preservation.

Locked Mathematical & Stoichiometry Formulas:

 Daily Lean-Mass Preservation Protein Target = 1.2 to 1.6 g × Ideal Body Weight (kg) divided across 3–4 leucine-threshold meals

1 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-LongevitySynth v4.2

Geroprotective, Mitochondrial & Renal eGFR Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-LongevitySynth v4.2 evaluates geroprotective clinical trials and enforces renal eGFR safety thresholds across medication and supplement guides.

Locked Mathematical & Stoichiometry Formulas:

Renal Safety Gate: Hold Metformin initiation if eGFR < 45 mL/min/1.73m²; contraindicated if eGFR < 30 mL/min/1.73m²

1 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-EndoAudit v4.2

Endocrine Society Thyroid, HOMA-IR & Hormone Assay Auditor

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-EndoAudit v4.2 audits thyroid, adrenal, and metabolic hormone guides, ensuring every lab cutoff accounts for circadian draw timing and assay interference.

Locked Mathematical & Stoichiometry Formulas:

Weight-Based Full Replacement Levothyroxine Estimate = 1.6 mcg × Ideal Body Weight (kg) [Titrated by 6-Week TSH]

1 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-CardioSynth v4.2

Lipidology, ApoB, Lp(a) & ASCVD Risk Synthesis Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-CardioSynth v4.2 synthesizes preventive cardiology and lipidology trials, explaining why direct ApoB particle counts and combination low-dose therapy outperform high-dose statin monotherapy.

Locked Mathematical & Stoichiometry Formulas:

 Statin Rule of 6: Initial starting dose achieves ~35%–42% LDL-C drop; each subsequent dose doubling adds ~6% further reduction while doubling myalgia risk.

1 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →

dotMD-GastroImmuno v4.2

ACG Microbiome, FODMAP Excipient & Mucosal Barrier Agent

Core Audit Role: ⚙ Zero-Hallucination Key Lock

dotMD-GastroImmuno v4.2 audits gastrointestinal condition guides and screens medication/supplement inactive ingredients for FODMAP polyols, artificial dyes, and mucosal irritants.

Locked Mathematical & Stoichiometry Formulas:

 PPI Washout Rule: Discontinue Proton Pump Inhibitors 14 days prior to H. pylori stool antigen or urea breath testing to prevent false-negative results.

1 Audited Flagship / Research Guides Inspect 4-Box Agent Spec →