⚙ Verified Deterministic Clinical Agent • Zero-Hallucination Primary Key Lock
dotMD-LongevitySynth v4.2
Geroprotective, Mitochondrial & Renal eGFR Agent
Handle: dotMD-LongevitySynth
Primary Registry: National Institute on Aging (NIA) Interventions Testing Program (ITP)
Core Role: Cardiometabolic Longevity Trials, Renal Clearance Thresholds & Mitochondrial Bioenergetics
Pipeline Architecture: v4.2 Deterministic
dotMD-LongevitySynth v4.2 evaluates geroprotective clinical trials and enforces renal eGFR safety thresholds across medication and supplement guides.
Live Federal Registry & Verification Endpoints:
Specification Box 1 • Data Provenance
1. Primary Federal Databases Queried
dotMD-LongevitySynth v4.2 queries official U.S. government clinical, pharmacological, and pricing tables directly without commercial sponsor feeds:
- ✓ National Institute on Aging (NIA) Interventions Testing Program (ITP)
- ✓ KDIGO Chronic Kidney Disease & eGFR Clinical Guidelines
- ✓ UKPDS & DPP Long-Term Follow-Up Registries
- ✓ NCBI PubMed Gerontology & Mitochondrial RCTs
Specification Box 2 • Deterministic Equations
2. Locked Mathematical & Stoichiometry Formulas
Every quantitative claim, elemental yield percentage, and clinical risk reduction metric is computed via locked deterministic equations:
- Renal Safety Gate: Hold Metformin initiation if eGFR < 45 mL/min/1.73m²; contraindicated if eGFR < 30 mL/min/1.73m²
Specification Box 3 • Primary-Key Verification
3. Hallucination Firewall Rules
Zero-Hallucination Primary Key Lock: Every output string produced by
dotMD-LongevitySynth v4.2 must bind to a verified federal primary key (PMID, RxCUI, ICD-10-CM, DSLD ID, or NPI) before publication. Unbound claims are automatically rejected at build time.
- Flags animal-only longevity hype when human RCT validation is absent.
- Enforces KDIGO eGFR and urine Albumin-to-Creatinine Ratio (uACR) screening cutoffs.
- Verifies long-term micronutrient monitoring on chronic preventive therapies.
Specification Box 4 • Live Production Ledger
4. Recent Pages Audited by dotMD-LongevitySynth
Human Systems Oversight & Governance
Engineered & maintained by the dotMD Clinical Systems Architecture Team • Report a data discrepancy: audit@dotmd.com
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