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Weight Management & Metabolic Syndrome • ICD-10-CM E88.09

Albumin - low

Also known as: Hypoalbuminemia

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E88.09 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Albumin - low Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Albumin - low?

Physicians managing Albumin - low (also termed Hypoalbuminemia) (E88.09; Weight Management & Metabolic Syndrome) utilize body composition DEXA in Albumin - low (E88.09: or waist-circumference anthropometry) and objective Waist-to-Height Ratio [Albumin - low E88.09] targets (< 0.50 (E88.09)) to prevent progression and functional morbidity.

Pathophysiology, Underlying Causes & Clinical Presentation

In Albumin - low (E88.09), physiological disruption stems from hypothalamic arcuate nucleus in Albumin - low (E88.09: leptin resistance), informing Weight Management & Metabolic Syndrome protocols that track HOMA-IR Insulin Resistance in Albumin - low (E88.09: Index) (< 1.4 (E88.09)).

Common Symptoms & Clinical Signs

  • • Presentation of Albumin - low (E88.09): daytime sluggishness or in Albumin - low (E88.09: loud snoring linked)
  • • Secondary Albumin - low clinical sign: central abdominal visceral in Albumin - low (E88.09: fat accumulation resistant)
  • • Symptom flares in Albumin - low correlating with Waist-to-Height Ratio [Albumin - low E88.09] deviation outside < 0.50 (E88.09)
  • • Functional weight & metabolism impact requiring body composition DEXA in Albumin - low (E88.09: or waist-circumference anthropometry) evaluation (E88.09)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Albumin - low Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E88.09 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Weight Management & Metabolic Syndrome NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Waist-to-Height Ratio [Albumin - low E88.09] < 0.50 (E88.09) Clinical Reference Target Range
Diagnostic / Lab Marker: HOMA-IR Insulin Resistance in Albumin - low (E88.09: Index) < 1.4 (E88.09) Clinical Reference Target Range
Diagnostic / Lab Marker: ALT & Fasting in Albumin - low (E88.09: Triglycerides) ALT < 25 U/L; TG < 100 mg/dL (E88.09) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Albumin - low

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Albumin Human Albuminex • RxCUI RXN-642082510-2793 Human Serum Albumin 76% $2.7800 $ 121.09 /mo
Volumex (Iodinated I-131 Albumin) Volumex • RxCUI RXN-B509147720 Radiopharmaceutical Activity [MoA] 77% $0.5200 $ 45.94 /mo
Megatope (Iodinated I-131 Albumin) Megatope • RxCUI RXN-B509147731 Radiopharmaceutical Activity [MoA] 77% $3.0700 $ 229.54 /mo
Iodinated I-131 Albumin Megatope, Volumex • RxCUI RXN-509147731-1994 Radiopharmaceutical Activity [MoA] 75% $0.5600 $ 31.18 /mo
Albuminex (Albumin Human) Albuminex • RxCUI RXN-B642082510 Human Serum Albumin 77% $1.1500 $ 91.30 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Albumin - low)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on GLP-1-based therapies and limb outcomes in: What a 240,000-Participant Study Found

In real-world PAD populations, GLP-1-based therapies are associated with meaningful reductions in both limb and heart and blood vessel outcomes.

Diabetes research and clinical practice • 2026-06-15 • Meta-Analysis
N = 240,000 94/100 PMID 42009258 ↗
New Insights on Weight maintenance and additional weight loss with liraglutide after: What a 422-Participant Study Found

Liraglutide, with diet and exercise, maintained weight loss achieved by caloric restriction and induced further weight loss over 56 weeks.

International journal of obesity (2005) • 2013-11-15 • Randomized Controlled Trial
N = 422 93/100 PMID 23812094 ↗
New Insights on Urinary dipeptidyl peptidase-4 protein is increased by linagliptin and is a: What a 360-Participant Study Found

This might suggest a varying degree of importance of DPP-4 as a pathophysiological factor in T2D-associated kidney disease.

Diabetes, obesity & metabolism • 2021-08-15 • Phase III Randomized Trial
N = 360 93/100 PMID 33881796 ↗
New Insights on Effect of Subcutaneous Semaglutide vs Placebo as an add-on booster to Intensive: What a 611-Participant Study Found

Of 611 randomized participants (495 women [81.0%], mean age 46 years [SD, 13], body weight 105.8 kg [SD, 22.9], and body mass index 38.0 [SD, 6.7]), 567 (92.8%) completed the trial, and 505 (82.7%) were receiving treatment at...

JAMA • 2021-04-13 • Phase III Randomized Trial
N = 611 93/100 PMID 33625476 ↗
What the Latest Evidence Really Says About GLP-1 Receptor/Dual Agonists for Weight

Tirzepatide and Semaglutide_SC are most effective for clinically meaningful weight loss.

Diabetes, obesity & metabolism • 2026-06-15 • Meta-Analysis
Multi-cohort 92/100 PMID 41872986 ↗
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