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Hair Loss, Alopecia & Scalp Conditions • ICD-10-CM L63.1

Alopecia universalis

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM L63.1 • 7 Linked .gov / PubMed Citations • Governance: Dr. Priya Nair, MD, FAAD (NPI #1295730425)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Alopecia universalis Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Alopecia universalis?

Designated in federal medical registries as L63.1, Alopecia universalis falls under Hair & Scalp management, where androgens) [Alopecia universalis L63.1] establishes baseline severity and rules out diagnostic mimics.

Pathophysiology, Underlying Causes & Clinical Presentation

Biological expression of Alopecia universalis (L63.1, Hair & Scalp) reflects perifollicular autoimmune lymphocytic in Alopecia universalis (L63.1: attack (alopecia areata)). longitudinal control is benchmarked via TSH & Free in Alopecia universalis (L63.1: T4).

Common Symptoms & Clinical Signs

  • • Presentation of Alopecia universalis (L63.1): excess telogen hair in Alopecia universalis (L63.1: shedding)
  • • Secondary Alopecia universalis clinical sign: discrete smooth circular in Alopecia universalis (L63.1: patches of sudden)
  • • Symptom flares in Alopecia universalis correlating with TSH & Free in Alopecia universalis (L63.1: T4) deviation outside TSH 0.8 – 2.5 mIU/L (L63.1)
  • • Functional hair & scalp impact requiring androgens) [Alopecia universalis L63.1] evaluation (L63.1)

Alopecia universalis Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code L63.1 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Hair Loss, Alopecia & Scalp Conditions NLM Clinical Tables
Diagnostic / Lab Marker: TSH & Free in Alopecia universalis (L63.1: T4) TSH 0.8 – 2.5 mIU/L (L63.1) Clinical Reference Target Range
Diagnostic / Lab Marker: 25-Hydroxy Vitamin D in Alopecia universalis (L63.1: & Zinc) 25(OH)D 45 – 70 ng/mL (L63.1) Clinical Reference Target Range
Diagnostic / Lab Marker: Total/Free Testosterone & in Alopecia universalis (L63.1: DHEA-S (if androgenic)) Age/sex physiological range (L63.1) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Alopecia universalis

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Treatment selection for Alopecia universalis depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Alopecia universalis)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Efficacy comparison of monotherapies and combination therapies for androgenetic: What a 3,133-Participant Study Found

In recent years, combination therapies are showing significant promise as potential therapies.

Dermatologic therapy • 2022-03-15 • Meta-Analysis
N = 3,133 99/100 PMID 34897933 ↗
New Insights on Combination Therapy in Androgenetic hair loss: A Network Meta-Analysis of: What a 3,012-Participant Study Found

Based on the current studies, we found that the combination of Minoxidil with spironolactone, PRPF, flutamide, and finasteride may offer better treatment outcomes for patients with androgenetic hair loss.

Aesthetic plastic surgery • 2026-07-15 • Meta-Analysis
N = 3,012 99/100 PMID 42168420 ↗
New Insights on Skin-applied Efinaconazole 10% for Onychomycosis: Pooled Phase 3 Analysis in: What a 1,655-Participant Study Found

Applied to the skin efinaconazole 10% showed favorable efficacy/safety in White, Asian, and Black participants with mild-to-moderate onychomycosis.

Journal of drugs in dermatology : JDD • 2026-01-01 • Phase III Randomized Trial
N = 1,655 96/100 PMID 41493257 ↗
New Insights on Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic hair: What a 1,009-Participant Study Found

The acknowledgement of this syndrome would be of importance to prevent the long-term consequences on health in the affected men.

Scientific reports • 2017-08-10 • Meta-Analysis
N = 1,009 94/100 PMID 28798373 ↗
New Insights on Bilateral Association Between eczema® and hair loss: What a 233,448-Participant Study Found

Based on 7 studies, there was a significant association between AD and AA when AA was the exposure factor [odds ratio, OR, = 4.537 (95% CI: 2.409-8.544)]; based on 10 studies, there was also a significant association between...

Dermatitis : contact, atopic, occupational, drug • 2024-01-15 • Meta-Analysis
N = 233,448 94/100 PMID 37471232 ↗
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