Bipolar Disorder
Also known as: Manic depression, Manic-depressive illness, Disorder, Syndrome, Diseases
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Bipolar Disorder Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: What is bipolar disorder? Bipolar disorder is a mood disorder that can cause intense mood swings: Sometimes you may feel extremely "up," elated, irritable, or energized.
- 2 Real-world patient consensus: Diagnostic registry F31.60: Bipolar Disorder is managed within Depression & Mood (aka Manic depression).
- 3 Typical cash cost range: Differential triage of Bipolar Disorder (F31.60) utilizes safety/support screening [Bipolar Disorder F31.60].
- 4 Top reported side effects / signs: Objective lab/clinical target for Bipolar Disorder: PHQ-9 Symptom Severity in Bipolar Disorder (F31.60: Score) (< 4 (clinical remission) (F31.60)) and TSH & Free in Bipolar Disorder (F31.60: T4 Rule-Out).
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What Is Bipolar Disorder?
What is bipolar disorder? Bipolar disorder is a mood disorder that can cause intense mood swings: Sometimes you may feel extremely "up," elated, irritable, or energized. This is called a manic episode . Other times you may feel "down," sad, indifferent, or hopeless. This is called a depressive episode . You may have both manic and depressive symptoms together. This is called a mixed episode . Along with mood swings, bipolar disorder causes changes in behavior, energy levels, and activity levels. Bipolar disorder used to be called other names, including manic depression and manic-depressive disorder.
Pathophysiology, Underlying Causes & Clinical Presentation
Pathophysiologically, Bipolar Disorder (ICD-10 F31.60) is driven by circadian phase instability [Bipolar Disorder F31.60]; Cross-referenced with NIH MeSH (Bipolar Disorder), specialists in Depression, Bipolar & Mood Disorders monitor TSH & Free in Bipolar Disorder (F31.60: T4 Rule-Out) to gauge tissue recovery.
Common Symptoms & Clinical Signs
- • Sometimes you may feel extremely "up," elated, irritable, or energized. This is called a manic episode
- • Other times you may feel "down," sad, indifferent, or hopeless. This is called a depressive episode
- • Presentation of Bipolar Disorder (F31.60): persistent low mood, in Bipolar Disorder (F31.60: emotional flatness, or)
- • Secondary Bipolar Disorder clinical sign: disrupted sleep architecture [Bipolar Disorder F31.60]
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Bipolar Disorder Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | F31.60 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | Depression, Bipolar & Mood Disorders | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Bipolar Disorder (F31.60: Score) | < 4 (clinical remission) (F31.60) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: TSH & Free in Bipolar Disorder (F31.60: T4 Rule-Out) | TSH 0.8 – 2.5 mIU/L (F31.60) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Serum Vitamin D in Bipolar Disorder (F31.60: & RBC Folate) | 25(OH)D 40 – 65 ng/mL (F31.60) | Clinical Reference Target Range |
FDA-Monographed Medications & Public Cash Price Reference for Bipolar Disorder
Treatment selection for Bipolar Disorder depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Bipolar Disorder)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Efficacy of Lumateperone in Patients With Bipolar Depression With Mixed: What a 376-Participant Study Found Conclusions: Lumateperone 42 mg significantly improved symptoms of depression and disease severity in patients with an MDE associated with bipolar I or bipolar II disorder, with or without mixed features. The Journal of clinical psychiatry • 2023-04-24 • Phase III Randomized Trial | N = 376 | 93/100 | PMID 37103915 ↗ |
| New Insights on Wuling Capsule for: What a 340-Participant Study Found Adjunctive Wuling capsule may augment the effects of antidepressants and may be associated with fewer adverse drug reactions. East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan • 2016-09-15 • Meta-Analysis | N = 340 | 91/100 | PMID 27703096 ↗ |
| Can This Approach Help? Inside the Latest Research on Weight changes in postpartum women with remitted Weight loss was not compromised by antidepressant pharmacotherapy. The Journal of clinical psychiatry • 2005-03-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 15766293 ↗ |
| Can This Approach Help? Inside the Latest Research on Duration of Adjunctive Antidepressant Maintenance in Bipolar I In a trial involving patients with bipolar I disorder and a recently remitted depressive episode, adjunctive treatment with escitalopram or bupropion XL that continued for 52 weeks did not show a significant benefit as... The New England journal of medicine • 2023-08-03 • Randomized Controlled Trial | N = 90 | 88/100 | PMID 37530824 ↗ |
| Can This Approach Help? Inside the Latest Research on Antidepressants effects of Rhodiola capsule combined with sertraline for It is concluded that the Rhodiola capsule shows anti-depressive potency in patients with depression disorder when administered in dosages of either 0.3 or 0.6 g/day over a 12-week period.Rhodiola capsule can improve the... Journal of affective disorders • 2020-03-15 • Randomized Controlled Trial | N = 100 | 88/100 | PMID 32090788 ↗ |
Bipolar Disorder Patient Community & “People Like Me” Threads
Filter Bipolar Disorder community threads and patient logs by age, biological sex, dosage, and treatment duration.