Leishmaniasis
Also known as: Kala-azar
Methodology & AI Transparency ⓘ
Leishmaniasis Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Leishmaniasis is a parasitic disease spread by the bite of infected sand flies.
- 2 Real-world patient consensus: Mapped to Depression, Bipolar & Mood Disorders under ICD-10-CM F39.9 for Leishmaniasis clinical workups.
- 3 Typical cash cost range: Clinicians assessing Leishmaniasis focus on monoaminergic (serotonin [Leishmaniasis F39.9] and targeted history.
- 4 Top reported side effects / signs: Key Depression & Mood biomarkers for Leishmaniasis (F39.9): Serum Vitamin D in Leishmaniasis (F39.9: & RBC Folate) & PHQ-9 Symptom Severity in Leishmaniasis (F39.9: Score) (< 4 (clinical remission) (F39.9)).
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What Is Leishmaniasis?
Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. There are several different forms of leishmaniasis. The most common are cutaneous and visceral. The cutaneous type causes skin sores. The visceral type affects internal organs such as the spleen, liver, and bone marrow. People with this form usually have fever, weight loss, and an enlarged spleen and liver. Leishmaniasis is found in parts of about 88 countries. Most of these countries are in the tropics and subtropics. It is possible but very unlikely that you would get this disease in the United States.
Pathophysiology, Underlying Causes & Clinical Presentation
Leishmaniasis (F39.9) alters depression & mood homeostasis through monoaminergic (serotonin [Leishmaniasis F39.9]; Cross-referenced with NIH MeSH (Leishmaniasis), clinical remission targets PHQ-9 Symptom Severity in Leishmaniasis (F39.9: Score) within < 4 (clinical remission) (F39.9).
Common Symptoms & Clinical Signs
- • Stay indoors from dusk to dawn, when sand flies are the most active
- • Wear long pants and long-sleeved shirts when outside
- • Presentation of Leishmaniasis (F39.9): disrupted sleep architecture [Leishmaniasis F39.9]
- • Secondary Leishmaniasis clinical sign: slowed concentration, indecisiveness, in Leishmaniasis (F39.9: and physical heaviness)
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Leishmaniasis Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | F39.9 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | Depression, Bipolar & Mood Disorders | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: Serum Vitamin D in Leishmaniasis (F39.9: & RBC Folate) | 25(OH)D 40 – 65 ng/mL (F39.9) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: PHQ-9 Symptom Severity in Leishmaniasis (F39.9: Score) | < 4 (clinical remission) (F39.9) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: TSH & Free in Leishmaniasis (F39.9: T4 Rule-Out) | TSH 0.8 – 2.5 mIU/L (F39.9) | Clinical Reference Target Range |
FDA-Monographed Medications & Public Cash Price Reference for Leishmaniasis
Treatment selection for Leishmaniasis depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Leishmaniasis)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients: What a 230-Participant Study Found This study confirmed rapid and robust reduction of depressive symptoms with esketamine nasal spray in severely ill patients with MDD who have active suicidal ideation with intent. The international journal of neuropsychopharmacology • 2021-01-20 • Phase III Randomized Trial | N = 230 | 88/100 | PMID 32861217 ↗ |
| Can This Approach Help? Inside the Latest Research on Assessing expectancy and suggestibility in a trial of escitalopram v. psilocybin Our results suggest that psychedelic therapy may be less vulnerable to expectancy biases than previously suspected. Psychological medicine • 2024-06-15 • Randomized Controlled Trial | N = 55 | 88/100 | PMID 38247730 ↗ |
| Can This Approach Help? Inside the Latest Research on Sertraline, venlafaxine and desipramine effects on depression, cognition and the In this trial, sertraline treatment was associated with superior effectiveness in relation to depressive, cognitive, and behavioral symptoms. Pharmacopsychiatry • 2014-07-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 24955552 ↗ |
| Can This Approach Help? Inside the Latest Research on A pooled analysis of suicidality in gold-standard blind, compared against a dummy Results of short-term, all-duration, and psychiatric studies analyses, as well as age-group analyses, performed in accordance with the FDA-specified search strategy, show no significant increase in suicidality risk in adult... The Journal of clinical psychiatry • 2009-05-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 19552866 ↗ |
| Can This Approach Help? Inside the Latest Research on AmBisome single-drug treatment and Combination AmBisome-Miltefosine Therapy for Combination therapy appears to be safe, well tolerated, and effective, and halves treatment duration of current recommendations. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2022-10-12 • Phase III Randomized Trial | Multi-cohort | 82/100 | PMID 35147680 ↗ |
Leishmaniasis Patient Community & “People Like Me” Threads
Filter Leishmaniasis community threads and patient logs by age, biological sex, dosage, and treatment duration.