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Cancer, Oncology & Supportive Care • ICD-10-CM D48.19

Cancer

Also known as: Carcinoma, Malignancy, Neoplasms, Tumor, Neoplasia

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM D48.19 • 8 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Cancer Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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3 of 3 Free Questions Remaining

What Is Cancer?

What is cancer? Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer, while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of your body. The spread of cancer from one part of the body to another is called metastasis.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Cancer (D48.19) center on local tissue remodeling [Cancer D48.19]. Cross-referenced with NIH MeSH (Neoplasms), targeted cancer & oncology interventions aim to normalize Complete Blood Count in Cancer (D48.19: (ANC, Hemoglobin, Platelets)).

Common Symptoms & Clinical Signs

  • • Exposure to ultraviolet (UV) rays from the sun
  • • Physical inactivity
  • • Presentation of Cancer (D48.19): persistent painless lump, in Cancer (D48.19: non-healing ulcer/mole change,)
  • • Secondary Cancer clinical sign: unintended weight loss [Cancer D48.19]

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Cancer Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code D48.19 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Cancer, Oncology & Supportive Care NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Complete Blood Count in Cancer (D48.19: (ANC, Hemoglobin, Platelets)) Safe hematologic reserve (D48.19) Clinical Reference Target Range
Diagnostic / Lab Marker: Comprehensive Metabolic & in Cancer (D48.19: Organ Function Panel) Preserved renal/hepatic clearance (D48.19) Clinical Reference Target Range
Diagnostic / Lab Marker: Pathology / Molecular in Cancer (D48.19: Genomic Staging) Guideline-concordant surveillance (D48.19) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Cancer

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Treatment selection for Cancer depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Cancer)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Integrating NCCN and LATITUDE in metastatic castration-sensitive prostate cancer:: What a 1,052-Participant Study Found

While further stratification by metastasis timing suggested no clear survival benefit in the double low synchronous subgroup, wide CIs indicate substantial uncertainty.

World journal of urology • 2026-08-19 • Phase III Randomized Trial
N = 1,052 96/100 PMID 42616151 ↗
New Insights on Age-related real-world benefits and safety of Darolutamide Plus: What a 1,086-Participant Study Found

In the 219 patients aged ≥75 yr in ARASENS, darolutamide demonstrated improved efficacy versus placebo and favorable safety, consistent with the findings in patients aged <75 yr.

European urology oncology • 2026-06-15 • Phase III Randomized Trial
N = 1,086 96/100 PMID 41193271 ↗
New Insights on Veliparib concomitant with first-line chemotherapy and as maintenance therapy in: What a 1,140-Participant Study Found

No OS or DRS benefit of addition of veliparib to platinum-based chemotherapy and continued as maintenance therapy was detected in this study, despite an observed.

European journal of cancer (Oxford, England : 1990) • 2025-07-25 • Phase III Randomized Trial
N = 1,140 96/100 PMID 40561681 ↗
New Insights on Development and validation of a multivariable prognostic model in de novo: What a 1,058-Participant Study Found

A prognostic model for men with de novo mCSPC was developed and validated in an independent testing set.

Prostate cancer and prostatic diseases • 2023-03-15 • Phase III Randomized Trial
N = 1,058 96/100 PMID 35790787 ↗
New Insights on Effect of concomitant statin treatment in postmenopausal patients with hormone: What a 3,420-Participant Study Found

According to this analysis, hydrophilic statins showed a detrimental effect on DFS in the main model, which was attenuated after correction for confounders.

ESMO open • 2022-04-15 • Phase III Randomized Trial
N = 3,420 96/100 PMID 35334418 ↗
Zero-PHI Patient Support & Cohort Discussions

Cancer Patient Community & “People Like Me” Threads

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