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Alzheimer, Dementia & Memory Health • ICD-10-CM G31.9

Degenerative disease of nervous system

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM G31.9 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Degenerative disease of nervous system Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Degenerative disease of nervous system?

Designated in federal medical registries as G31.9, Degenerative disease of nervous system falls under Memory & Cognition management, where targeted plasma/CSF biomarker in Degenerative disease of nervous system (G31.9: evaluation when indicated) establishes baseline severity and rules out diagnostic mimics.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Degenerative disease of nervous system (G31.9) center on neuroinflammatory microglial activation [Degenerative disease of nervous system G31.9]. targeted memory & cognition interventions aim to normalize TSH & Fasting in Degenerative disease of nervous system (G31.9: ApoB / HbA1c).

Common Symptoms & Clinical Signs

  • • Presentation of Degenerative disease of nervous system (G31.9): slowed processing speed in Degenerative disease of nervous system (G31.9: compared with prior)
  • • Secondary Degenerative disease of nervous system clinical sign: short-term recall difficulty in Degenerative disease of nervous system (G31.9: for recent conversations,)
  • • Symptom flares in Degenerative disease of nervous system correlating with TSH & Fasting in Degenerative disease of nervous system (G31.9: ApoB / HbA1c) deviation outside Optimal cardiometabolic neuroprotection (G31.9)
  • • Functional memory & cognition impact requiring targeted plasma/CSF biomarker in Degenerative disease of nervous system (G31.9: evaluation when indicated) evaluation (G31.9)

Degenerative disease of nervous system Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code G31.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Alzheimer, Dementia & Memory Health NLM Clinical Tables
Diagnostic / Lab Marker: TSH & Fasting in Degenerative disease of nervous system (G31.9: ApoB / HbA1c) Optimal cardiometabolic neuroprotection (G31.9) Clinical Reference Target Range
Diagnostic / Lab Marker: MoCA Cognitive Screening in Degenerative disease of nervous system (G31.9: Score) >= 26 / 30 (G31.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Homocysteine & Vitamin in Degenerative disease of nervous system (G31.9: B12) Homocysteine < 9 umol/L; B12 > 500 pg/mL (G31.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Degenerative disease of nervous system

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Treatment selection for Degenerative disease of nervous system depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Degenerative disease of nervous system)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Pimavanserin safety in adult and older adults patients with neuropsychiatric: What a 595-Participant Study Found

The mean.

Journal of Alzheimer's disease : JAD • 2025-07-15 • Phase III Randomized Trial
N = 595 93/100 PMID 40518812 ↗
Can This Approach Help? Inside the Latest Research on Brexpiprazole's impacts on patients and caregivers in agitation in Alzheimer's

At Week 10, the differences of brexpiprazole 1 and 2 mg versus placebo for NPI total score were -1.2 (p = 0.5891) and -8.4 (p < 0.0001), and those for NPI-Distress total score were -1.1 (p = 0.2292) and -3.9 (p < 0.0001),...

Alzheimer's & dementia : the journal of the Alzheimer's Association • 2025-07-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 40717666 ↗
Can This Approach Help? Inside the Latest Research on Safety Profile of Pimavanserin Therapy in older adults Patients with

Pimavanserin was well tolerated and not associated with motor or cognitive impairment.

Journal of Alzheimer's disease : JAD • 2024-01-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 38427485 ↗
Can This Approach Help? Inside the Latest Research on Safety and real-world benefits of pimavanserin in patients with Lewy body

Psychosis relapse risk was significantly lower with pimavanserin vs.

BMC neurology • 2025-11-24 • Phase III Randomized Trial
N = 22 88/100 PMID 41286676 ↗
Can This Approach Help? Inside the Latest Research on Exploration of baseline and early changes in neurocognitive characteristics as

These exploratory results warrant further scrutiny, but demonstrate that quick and non-invasive behavioral tests may have substantial clinical value in predicting antidepressant treatment response.

Psychological medicine • 2022-10-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 33213541 ↗
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Degenerative disease of nervous system Patient Community & “People Like Me” Threads

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