Erectile Dysfunction
Also known as: ED, Impotence
Methodology & AI Transparency ⓘ
Erectile Dysfunction Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Erectile dysfunction (ED) is a common type of male sexual dysfunction.
- 2 Real-world patient consensus: Diagnostic registry N52.9: Erectile Dysfunction is managed within Men's Health & TRT (aka ED).
- 3 Typical cash cost range: Clinicians assessing Erectile Dysfunction focus on impaired cavernosal endothelial in Erectile Dysfunction (N52.9: nitric oxide-cGMP smooth-muscle) and targeted history.
- 4 Top reported side effects / signs: Follow-up benchmark in Erectile Dysfunction: maintaining LH, FSH & in Erectile Dysfunction (N52.9: SHBG) within LH/FSH 2.5 – 8.0 mIU/mL (N52.9).
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What Is Erectile Dysfunction?
Erectile dysfunction (ED) is a common type of male sexual dysfunction. It is when a man has trouble getting or keeping an erection. ED becomes more common as you get older. But it's not a natural part of aging. Some people have trouble speaking with their doctors about sex. But if you have ED, you should tell your doctor. ED can be a sign of health problems. It may mean your blood vessels are clogged. It may mean you have nerve damage from diabetes. If you don't see your doctor, these problems will go untreated. Your doctor can offer several new treatments for ED. For many men, the answer is as simple as taking a pill.
Pathophysiology, Underlying Causes & Clinical Presentation
Tissue-level etiology in Erectile Dysfunction (N52.9) features impaired cavernosal endothelial in Erectile Dysfunction (N52.9: nitric oxide-cGMP smooth-muscle). Cross-referenced with NIH MeSH (Erectile Dysfunction), therapeutic stabilization in men's health & trt is verified against Hematocrit & Total in Erectile Dysfunction (N52.9: PSA).
Common Symptoms & Clinical Signs
- • Presentation of Erectile Dysfunction (N52.9): reduced sexual desire, in Erectile Dysfunction (N52.9: fewer spontaneous morning)
- • Secondary Erectile Dysfunction clinical sign: loss of lean in Erectile Dysfunction (N52.9: muscle recovery, rising)
- • Symptom flares in Erectile Dysfunction correlating with LH, FSH & in Erectile Dysfunction (N52.9: SHBG) deviation outside LH/FSH 2.5 – 8.0 mIU/mL (N52.9)
- • Functional men's health & trt impact requiring sleep-apnea [Erectile Dysfunction N52.9] evaluation (N52.9)
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Erectile Dysfunction Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | N52.9 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | Men's Health, Testosterone & Sexual Function | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: LH, FSH & in Erectile Dysfunction (N52.9: SHBG) | LH/FSH 2.5 – 8.0 mIU/mL (N52.9) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Hematocrit & Total in Erectile Dysfunction (N52.9: PSA) | Hct < 50%; age-appropriate PSA (N52.9) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Ultrasensitive Estradiol & in Erectile Dysfunction (N52.9: ApoB) | E2 20–38 pg/mL; ApoB < 80 mg/dL (N52.9) | Clinical Reference Target Range |
FDA-Monographed Medications & Public Cash Price Reference for Erectile Dysfunction
| Medication | Pharmacologic Class | Patient Worth-It | CMS NADAC / Unit | Typical Lowest Cash |
|---|---|---|---|---|
| Clomiphene Citrtae Clomiphene Citrate • RxCUI 1093060 | Estrogen Agonist/Antagonist | 84% | $4.0614 | $ 172.99 /mo |
| Vardenafil Hydrochloride Levitra • RxCUI 349479 | Phosphodiesterase 5 Inhibitor | 78% | $6.2103 | $ 48.70 /mo |
| Sildenafil Revatio • RxCUI 314229 | Phosphodiesterase 5 Inhibitor | 74% | $0.1029 | $ 5.84 /mo |
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Erectile Dysfunction)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Testosterone supplementation and bone: What a 3,103-Participant Study Found TRT is able to inhibit bone resorption and increase bone mass, particularly at the lumbar spine level and when the duration is long enough to allow the anabolic effect of T and estrogens on bone metabolism to take place. Journal of endocrinological investigation • 2022-05-15 • Meta-Analysis | N = 3,103 | 99/100 | PMID 35041193 ↗ |
| New Insights on Testosterone Therapy for Late-Onset Hypogonadism Improves Erectile: What a 1,458-Participant Study Found TTh achieved a significant improvement in the IIEF-EFD score of hypogonadal men compared with placebo, especially in those who received testosterone gel, were treated for over 30 weeks, and had no comorbidities. Urologia internationalis • 2022-01-15 • Meta-Analysis | N = 1,458 | 99/100 | PMID 34856556 ↗ |
| New Insights on Efficacy of tadalafil in clinical: What a 321-Participant Study Found Tadalafil was effective in improving erectile function across a wide spectrum of ED patients including patients with various comorbid conditions. The journal of sexual medicine • 2005-07-15 • Meta-Analysis | N = 321 | 97/100 | PMID 16422847 ↗ |
| New Insights on Baseline Total Testosterone Level on Successful Treatment of Sexual Dysfunction: What a 1,075-Participant Study Found Low TT levels at baseline did not negatively influence response to tadalafil in men of advancing age with concomitant lower urinary tract symptoms and benign prostatic hyperplasia and erectile dysfunction. The journal of sexual medicine • 2016-05-15 • Randomized Controlled Trial | N = 1,075 | 96/100 | PMID 27017071 ↗ |
| New Insights on Monotherapies and Combination Therapy of Tamsulosin and Tadalafil for Treating: What a 1,531-Participant Study Found Tadalafil combined with tamsulosin was more effective in the treatment of male LUTS/BPH, with or without ED, on the improvement of total IPSS, QoL, and Qmax. Urologia internationalis • 2024-01-15 • Meta-Analysis | N = 1,531 | 94/100 | PMID 38081154 ↗ |
Erectile Dysfunction Patient Community & “People Like Me” Threads
Filter Erectile Dysfunction community threads and patient logs by age, biological sex, dosage, and treatment duration.