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Men's Health, Testosterone & Sexual Function • ICD-10-CM N52.5

Sexual Problems in Men

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM N52.5 • 8 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Sexual Problems in Men Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Sexual Problems in Men?

Many men have sexual problems. They become more common as men age. Problems can include: Erectile dysfunction Reduced or lost interest in sex Problems with ejaculation Low testosterone Stress, illness, medicines, or emotional problems may also be factors. Occasional problems with sexual function are common. If problems last more than a few months or cause distress for you or your partner, you should see your health care provider.

Pathophysiology, Underlying Causes & Clinical Presentation

Underlying Sexual Problems in Men (code N52.5) is primary testicular Leydig in Sexual Problems in Men (N52.5: cell insufficiency or), Cross-referenced with NIH MeSH (Sexual Dysfunction, Physiological), which Men's Health, Testosterone & Sexual Function clinicians address while surveilling Hematocrit & Total in Sexual Problems in Men (N52.5: PSA) (Hct < 50%; age-appropriate PSA (N52.5)).

Common Symptoms & Clinical Signs

  • • Erectile dysfunction
  • • Reduced or lost interest in sex
  • • Presentation of Sexual Problems in Men (N52.5): loss of lean in Sexual Problems in Men (N52.5: muscle recovery, rising)
  • • Secondary Sexual Problems in Men clinical sign: blunted motivation, depressed in Sexual Problems in Men (N52.5: mood, or declining)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Sexual Problems in Men Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code N52.5 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Men's Health, Testosterone & Sexual Function NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Hematocrit & Total in Sexual Problems in Men (N52.5: PSA) Hct < 50%; age-appropriate PSA (N52.5) Clinical Reference Target Range
Diagnostic / Lab Marker: Ultrasensitive Estradiol & in Sexual Problems in Men (N52.5: ApoB) E2 20–38 pg/mL; ApoB < 80 mg/dL (N52.5) Clinical Reference Target Range
Diagnostic / Lab Marker: Morning Total & in Sexual Problems in Men (N52.5: Free Testosterone (2x) Total 500–900 ng/dL; Free 110–210 pg/mL (N52.5) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Sexual Problems in Men

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Sexual Problems in Men)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Baseline Total Testosterone Level on Successful Treatment of Sexual Dysfunction: What a 1,075-Participant Study Found

Low TT levels at baseline did not negatively influence response to tadalafil in men of advancing age with concomitant lower urinary tract symptoms and benign prostatic hyperplasia and erectile dysfunction.

The journal of sexual medicine • 2016-05-15 • Randomized Controlled Trial
N = 1,075 96/100 PMID 27017071 ↗
New Insights on Modeling and simulation of sexual activity daily diary data of patients with: What a 614-Participant Study Found

A modeling and simulation framework to support drug development in FSAD was developed.

Pharmaceutical research • 2006-08-15 • Randomized Controlled Trial
N = 614 93/100 PMID 16841199 ↗
New Insights on Tadalafil on lower urinary tract symptoms secondary to benign prostatic: What a 505-Participant Study Found

Tadalafil was efficacious and well tolerated in treating ED and LUTS/BPH in sexually active men with both conditions.

The journal of sexual medicine • 2013-08-15 • Randomized Controlled Trial
N = 505 93/100 PMID 23782459 ↗
New Insights on Benefits and safety of tadalafil 5 mg once-daily in Asian men with both lower: What a 361-Participant Study Found

Tadalafil is efficacious and well tolerated in the treatment of Asian men with both lower urinary tract symptoms associated with benign prostatic hyperplasia and erectile dysfunction.

International journal of urology : official journal of the Japanese Urological Association • 2019-02-15 • Phase III Randomized Trial
N = 361 93/100 PMID 30362173 ↗
What the Latest Evidence Really Says About Meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female

PDE5is could be an effective treatment modality for female sexual dysfunction.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics • 2016-05-15 • Meta-Analysis
Multi-cohort 92/100 PMID 26797204 ↗
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