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Acid Reflux, GERD & Upper GI Health • ICD-10-CM K21.00

Gastro-esophageal reflux disease with esophagitis, without bleeding

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM K21.00 • 7 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Gastro-esophageal reflux disease with esophagitis, without bleeding Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Gastro-esophageal reflux disease with esophagitis, without bleeding?

Gastro-esophageal reflux disease with esophagitis, without bleeding is an ICD-10-CM indexed diagnosis (K21.00) within Acid Reflux, GERD & Upper GI Health. Clinical evaluation centers on step-down acid suppression in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: review) alongside serial H. pylori Stool in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: Antigen or Urea) tracking (Negative (K21.00)) to guide individualized care.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in gerd & stomach, Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00) involves transient lower esophageal in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: sphincter relaxation). progression correlates with shifts in H. pylori Stool in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: Antigen or Urea) (Negative (K21.00)).

Common Symptoms & Clinical Signs

  • • Presentation of Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00): chronic throat clearing, in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: hoarseness, nocturnal cough,)
  • • Secondary Gastro-esophageal reflux disease with esophagitis, without bleeding clinical sign: nausea, belching, or in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: discomfort relieved or)
  • • Symptom flares in Gastro-esophageal reflux disease with esophagitis, without bleeding correlating with H. pylori Stool in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: Antigen or Urea) deviation outside Negative (K21.00)
  • • Functional gerd & stomach impact requiring step-down acid suppression in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: review) evaluation (K21.00)

Gastro-esophageal reflux disease with esophagitis, without bleeding Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code K21.00 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Acid Reflux, GERD & Upper GI Health NLM Clinical Tables
Diagnostic / Lab Marker: H. pylori Stool in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: Antigen or Urea) Negative (K21.00) Clinical Reference Target Range
Diagnostic / Lab Marker: Hemoglobin & Serum in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: Ferritin) Ferritin > 50 ng/mL (no occult loss) (K21.00) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin B12 in Gastro-esophageal reflux disease with esophagitis, without bleeding (K21.00: & Magnesium (chronic) B12 > 450 pg/mL; Mg >= 2.0 mg/dL (K21.00) Clinical Reference Target Range
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Treatment selection for Gastro-esophageal reflux disease with esophagitis, without bleeding depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Gastro-esophageal reflux disease with esophagitis, without bleeding)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Benefits and safety of Tofacitinib in Ulcerative Colitis Based on Prior Tumor: What a 1,139-Participant Study Found

Tofacitinib was efficacious in patients with UC regardless of prior TNFi failure status.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association • 2022-03-15 • Phase III Randomized Trial
N = 1,139 96/100 PMID 33684552 ↗
New Insights on Relationship between obstructive sleep apnea hypopnea syndrome and chronic acid: What a 2,699-Participant Study Found

The meta-analysis showed that there was a significant correlation between obstructive sleep apnea hypopnea syndrome and chronic acid reflux.

Sleep & breathing = Schlaf & Atmung • 2019-06-15 • Meta-Analysis
N = 2,699 94/100 PMID 29987514 ↗
New Insights on Association between obstructive sleep apnea and chronic acid: What a 2,950-Participant Study Found

There exists an association between OSA and chronic acid reflux that is independent of the modalities used for screening or diagnosing both disorders.

Journal of gastroenterology and hepatology • 2023-08-15 • Meta-Analysis
N = 2,950 94/100 PMID 37300443 ↗
New Insights on Olanzapine With or Without Fosaprepitant for Preventing Chemotherapy Induced: What a 690-Participant Study Found

This trial did not provide sufficient evidence to support that deletion of the NK-1 receptor antagonist was as good as keeping it, as a part of a 4-drug antiemetic regimen for highly emetogenic chemotherapy.

The oncologist • 2023-08-03 • Phase III Randomized Trial
N = 690 93/100 PMID 37284847 ↗
New Insights on Benefits and safety of GutGard® in Managing Gastroesophageal Reflux-Related: What a 296-Participant Study Found

The GutGard® group showed better and earlier resolution (within 2 weeks) of symptoms of GER as against the placebo group, especially heartburn and regurgitation.

Complementary medicine research • 2025-01-15 • Phase III Randomized Trial
N = 296 93/100 PMID 39929150 ↗
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