Acid Reflux, GERD & Upper GI Health • ICD-10-CM K21.1
Caffeine
Audited by the DotMD AI Specialist Council
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FDA DailyMed SPL: 2026-11-02 • ICD-10-CM K21.1 • 5 Linked .gov / PubMed Citations
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Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary
Caffeine Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: What is caffeine? Caffeine is a bitter substance that occurs naturally in more than 60 plants including: Coffee beans Tea leaves Kola nuts, which are used to flavor soft drink colas Cacao pods, which are used to make chocolate products There is also synthetic (man-made) caffeine, which is added to some medicines, foods, and drinks.
- 2 Real-world patient consensus: Federal ICD-10-CM code K21.1 categorizes Caffeine under Acid Reflux, GERD & Upper GI Health.
- 3 Typical cash cost range: Workup highlights for Caffeine (K21.1): step-down acid suppression in Caffeine (K21.1: review).
- 4 Top reported side effects / signs: Follow-up benchmark in Caffeine: maintaining Hemoglobin & Serum in Caffeine (K21.1: Ferritin) within Ferritin > 50 ng/mL (no occult loss) (K21.1).
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data
3 of 3 Free Questions RemainingAsk our AI Specialists anything about Caffeine
What Is Caffeine?
What is caffeine? Caffeine is a bitter substance that occurs naturally in more than 60 plants including: Coffee beans Tea leaves Kola nuts, which are used to flavor soft drink colas Cacao pods, which are used to make chocolate products There is also synthetic (man-made) caffeine, which is added to some medicines, foods, and drinks. For example, some pain relievers, cold medicines, and over-the-counter medicines for alertness contain synthetic caffeine. So do energy drinks and "energy-boosting" gums and snacks. Most people consume caffeine from drinks.
Pathophysiology, Underlying Causes & Clinical Presentation
Underlying Caffeine (code K21.1) is impaired esophageal peristaltic in Caffeine (K21.1: clearance), Cross-referenced with NIH MeSH (Caffeine), which Acid Reflux, GERD & Upper GI Health clinicians address while surveilling Hemoglobin & Serum in Caffeine (K21.1: Ferritin) (Ferritin > 50 ng/mL (no occult loss) (K21.1)).
Common Symptoms & Clinical Signs
- • Kola nuts, which are used to flavor soft drink colas
- • Cacao pods, which are used to make chocolate products
- • Presentation of Caffeine (K21.1): post-meal retrosternal heartburn in Caffeine (K21.1: or sour acid)
- • Secondary Caffeine clinical sign: epigastric burning, early in Caffeine (K21.1: satiety, or upper-abdominal)
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Caffeine Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | K21.1 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | Acid Reflux, GERD & Upper GI Health | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: Hemoglobin & Serum in Caffeine (K21.1: Ferritin) | Ferritin > 50 ng/mL (no occult loss) (K21.1) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Serum Vitamin B12 in Caffeine (K21.1: & Magnesium (chronic) | B12 > 450 pg/mL; Mg >= 2.0 mg/dL (K21.1) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: H. pylori Stool in Caffeine (K21.1: Antigen or Urea) | Negative (K21.1) | Clinical Reference Target Range |
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance
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FDA-Monographed Medications & Public Cash Price Reference for Caffeine
| Medication | Pharmacologic Class | Patient Worth-It | CMS NADAC / Unit | Typical Lowest Cash |
|---|---|---|---|---|
| Fioricet (Butalbital, Acetaminophen, and Caffeine) Fioricet • RxCUI RXN-B52544080 | Barbiturate | 76% | $8.8237 | $ 640.00 /mo |
| Butalbital, Aspirin, Caffeine and Codeine Phosphate Ascomp with Codeine • RxCUI RXN-636292952-2686 | Barbiturate | 87% | $0.9392 | $ 46.54 /mo |
| Norgesic (Orphenadrine Citrate, Aspirin and Caffeine) Norgesic • RxCUI RXN-B61825305 | Nonsteroidal Anti-inflammatory Drug | 91% | $5.8031 | $ 426.32 /mo |
| Midol (Acetaminophen, Caffeine, and Pyrilamine Maleate) Midol • RxCUI 1597298-B67751145 | Central Nervous System Stimulant | 77% | $0.0194 | $ 9.90 /mo |
| Caffeine Citrate Caffeine Citrate Generic • RxCUI 849931 | Central Nervous System Stimulant | 84% | $0.0877 | $ 12.05 /mo |
| Menstrual Relief (Acetaminophen, Caffeine, Pyrilamine Maleate) Menstrual Relief • RxCUI 1597298-B21130930 | Central Nervous System Stimulant | 92% | $0.0194 | $ 9.90 /mo |
| Bc Max (Aspirin, Acetaminophen, Caffeine) Bc Max • RxCUI 2360605-B63029203 | Nonsteroidal Anti-inflammatory Drug | 80% | $0.0667 | $ 13.30 /mo |
| Blowfish (Aspirin, Caffeine) Blowfish • RxCUI 1537019-B759200464 | Nonsteroidal Anti-inflammatory Drug | 74% | $0.0158 | $ 9.63 /mo |
| Exaprin Plus (Aspirin, Acetaminophen, Caffeine) Exaprin Plus • RxCUI 2723568 | Nonsteroidal Anti-inflammatory Drug | 82% | $0.0667 | $ 13.30 /mo |
| Butalbital, Aspirin, and Caffeine Butalbital, Aspirin, and Caffeine Generic • RxCUI 238134 | Barbiturate | 76% | $0.9482 | $ 46.90 /mo |
| Acetaminophen 500 Pyrilamine Maleate 15 and Caffeine 60 (Acetaminophen 500mg Pyrilamine Maleate 15mg and Caffeine 60mg Tablets) Acetaminophen 500 Pyrilamine Maleate 15 and Caffeine 60 • RxCUI 1597298-B71679312 | Central Nervous System Stimulant | 87% | $0.0194 | $ 9.90 /mo |
| Acetaminophen, Caffeine, Dihydrocodeine Bitartrate Trezix • RxCUI RXN-63187705-2880 | Central Nervous System Stimulant | 92% | $0.0194 | $ 9.29 /mo |
| Stay Awake (Caffeine) Stay Awake • RxCUI 198520 | Central Nervous System Stimulant | 74% | $0.0877 | $ 14.82 /mo |
| Ascomp with Codeine (Butalbital, Aspirin, Caffeine and Codeine Phosphate) Ascomp with Codeine • RxCUI RXN-B51991074 | Barbiturate | 81% | $0.9392 | $ 76.12 /mo |
| Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) Buscapina • RxCUI 1597298-B69729132 | Central Nervous System Stimulant | 90% | $0.0194 | $ 9.90 /mo |
| Butal/Apap/Caffeine Butal/Apap/Caffeine Generic • RxCUI RXN-72189600-2246 | Barbiturate | 92% | $0.7200 | $ 37.66 /mo |
Dr. Lin (AI PubMed Clinical Trial Lead)
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Caffeine)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| How Much Pre-Workout Caffeine Is Too Much? What Blood Tests Reveal About High Doses These findings suggest that acute CAF ingestion selectively influences post-exercise glucose responses during the CrossFit ® workout, whereas hematological variables and most biochemical markers remain unaffected. Journal of the International Society of Sports Nutrition • 2026-12-30 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 42924484 ↗ |
| New Insights on An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a: What a 210-Participant Study Found A caffeine-based applied to the skin liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic hair loss. Skin pharmacology and physiology • 2017-01-15 • Randomized Controlled Trial | N = 210 | 82/100 | PMID 29055953 ↗ |
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