Caffeine Citrate
Brand Names: Caffeine Citrate Generic
Methodology & AI Transparency ⓘ
Caffeine Citrate Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Indications and usage: Caffeine citrate injection and caffeine citrate oral solution are indicated for the short term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.
- 2 Real-world patient consensus: 84% patient "Worth It" rating across 20 anonymous logs for Caffeine Citrate (RxNorm 849931).
- 3 Typical cash cost range: Dispensing cost comparison spans $12.05 mail/discount cash up to $34.50 uninsured retail (federal NADAC $0.0877).
- 4 Top reported side effects / signs: Primary clinical safety signals tracked in FAERS for Caffeine Citrate include nausea (7.9%), headache (7.9%), dizziness (6.6%).
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Caffeine Citrate Mechanism, CYP450 Pathways & DailyMed Monograph
Indications and usage: Caffeine citrate injection and caffeine citrate oral solution are indicated for the short term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.
Mechanism of Action Caffeine is structurally related to other methylxanthines, theophylline, and theobromine. It is a bronchial smooth muscle relaxant, a CNS stimulant, a cardiac muscle stimulant, and a diuretic. Although the mechanism of action of caffeine in apnea of prematurity is not known, several mechanisms have been hypothesized.
Following administration (60 mg/3mL Injection), Caffeine Citrate achieves Complete (~100%) parenteral systemic delivery for Caffeine Citrate (60 mg/3mL Injection) bioavailability and rapid intravascular/parenteral onset within 15–45 minutes after caffeine citrate administration onset, governed by a Terminal t½ estimated at 4–17 hrs depending on renal/hepatic reserve (Caffeine Citrate) terminal half-life through caffeine citrate undergoes cyp1a2-mediated hepatic metabolism prior to excretion.
Before initiating Caffeine Citrate at 60 mg/3mL Injection, clinical safety checklists rule out contraindications caffeine citrate injection and caffeine citrate oral solution are contraindicated in patients who have demonstrated hypersensitivity to any of its components.; prior anaphylaxis, angioedema, or severe hypersensitivity to caffeine citrate or caffeine citrate excipients. Logged tolerability patterns center on nausea (7.9% of reports), headache (7.9% of reports), dizziness (6.6% of reports).
Potent CYP1A2 modulators alter hepatic clearance of Caffeine Citrate, shifting steady-state plasma concentrations.
Avoid overlapping central nervous system stimulant prescriptions alongside Caffeine Citrate to prevent cumulative receptor toxicity.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- CONTRAINDICATIONS Caffeine citrate injection and caffeine citrate oral solution are contraindicated in patients who have demonstrated hypersensitivity to any of its components.
- Prior anaphylaxis, angioedema, or severe hypersensitivity to Caffeine Citrate or Caffeine Citrate excipients
Logged Side-Effect Incidence (20 Reports)
Caffeine Citrate Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Caffeine Citrate)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| How Much Pre-Workout Caffeine Is Too Much? What Blood Tests Reveal About High Doses These findings suggest that acute CAF ingestion selectively influences post-exercise glucose responses during the CrossFit ® workout, whereas hematological variables and most biochemical markers remain unaffected. Journal of the International Society of Sports Nutrition • 2026-12-30 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 42924484 ↗ |
| New Insights on An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a: What a 210-Participant Study Found A caffeine-based applied to the skin liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic hair loss. Skin pharmacology and physiology • 2017-01-15 • Randomized Controlled Trial | N = 210 | 82/100 | PMID 29055953 ↗ |
Caffeine Citrate Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.0877/unit (~$2.63/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 20 Anonymous DotMD Community Micro-Logs | $12.05 / mo | View logs ↓ |
Caffeine Citrate Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Caffeine Citrate RxNorm Concept ID | 849931 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0877 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $12.05 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 84.00% Worth It (20 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Caffeine Citrate Patient Community, Cohort Filters & Dosage Logs
Deterministic Caffeine Citrate reference combining NIH RxNorm (849931), Medicaid NADAC ($0.0877/unit), and anonymous cohort outcomes (84% Worth It).
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Filter Caffeine Citrate community threads and patient logs by age, biological sex, dosage, and treatment duration.