Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate)
Brand Names: Buscapina
Methodology & AI Transparency ⓘ
Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Marketed under the trade name Buscapina (registered by OPMX LLC, RxNorm 1597298-B69729132), this over-the-counter branded formulation contains Acetaminophen, Caffeine, Pyrilamine Maleate within the Central Nervous System Stimulant therapeutic class.
- 2 Real-world patient consensus: Branded central nervous system stimulant presentation of Acetaminophen, Caffeine, Pyrilamine Maleate (OPMX LLC); generic reference: /meds/acetaminophen-caffeine-pyrilamine-maleate.
- 3 Typical cash cost range: 30-day cash pricing ranges from $9.90 discount cash to $34.50 walk-in retail (NADAC $0.0194/unit).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate): headache (10.1%), fatigue (5.6%), nausea (8.9%).
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Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) Mechanism, CYP450 Pathways & DailyMed Monograph
Marketed under the trade name Buscapina (registered by OPMX LLC, RxNorm 1597298-B69729132), this over-the-counter branded formulation contains Acetaminophen, Caffeine, Pyrilamine Maleate within the Central Nervous System Stimulant therapeutic class. Per 2024-12-03 DailyMed labeling (69729-132, 69729-130), clinical use centers on 500 mg/1 / 60 mg/1 Tablet, Coated; 15 mg/1 / 500 mg/1 Tablet, Coated: Uses for the temporary relief of these symptoms associated with menstrual periods: cramps bloating water-weight gain.
At the receptor and enzymatic level, Buscapina delivers Acetaminophen, Caffeine, Pyrilamine Maleate to execute central nervous system stimulant modulation with class-characteristic hepatorenal disposition. Specific to the Buscapina commercial product (NDC 69729-132, 69729-130, RxCUI 1597298-B69729132), tablet/vehicle compounding registered by OPMX LLC standardizes delivery across 500 mg/1 / 60 mg/1 Tablet, Coated; 15 mg/1 / 500 mg/1 Tablet, Coated, contrasting $9.90 discount cash access against $34.50 walk-in retail pricing.
With Mean elimination half-life of 10 to 16 hours across adult Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) dosing residence kinetics and Oral fraction absorbed ranges from 68% to 80% (Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) 500) bioavailability, Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) undergoes dual hepatorenal clearance pathway combining glucuronidation and urinary filtration of buscapina (acetaminophen, caffeine, pyrilamine maleate) and establishes therapeutic activity over oral tmax achieved within 2 to 3 hours following buscapina (acetaminophen, caffeine, pyrilamine maleate) ingestion.
Standard adult regimens span 500 mg/1 / 60 mg/1 Tablet, Coated, 15 mg/1 / 500 mg/1 Tablet, Coated, 500 mg/1 / 500 mg/1 Tablet, Film Coated. Prescribers screen specifically against confirmed ige-mediated allergy or cutaneous reaction to buscapina (acetaminophen, caffeine, pyrilamine maleate) (acetaminophen, caffeine, pyrilamine maleate) components; uncompensated hepatic or renal insufficiency incompatible with buscapina (acetaminophen, caffeine, pyrilamine maleate) (500 mg/1 / 60 mg/1 tablet, coated) clearance, while community micro-logs most frequently note headache (10.1% of reports), nausea (8.9% of reports), fatigue (5.6% of reports).
Reconcile eGFR-adjusted medications before escalating Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) in polypharmacy regimens.
Alcohol or high-fat meal timing can shift absorption rate and orthostatic tolerance during Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) dosing.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Confirmed IgE-mediated allergy or cutaneous reaction to Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) (Acetaminophen, Caffeine, Pyrilamine Maleate) components
- Uncompensated hepatic or renal insufficiency incompatible with Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) (500 mg/1 / 60 mg/1 Tablet, Coated) clearance
Logged Side-Effect Incidence (13 Reports)
Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate))
Human clinical trial evidence for Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.0194/unit (~$0.58/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 13 Anonymous DotMD Community Micro-Logs | $9.90 / mo | View logs ↓ |
| AgelessRx Geroprotective Telehealth (Licensed Telehealth Cash Program) | State-licensed clinician review • ~3d mail fulfillment | $65.00/mo program | Program details |
Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) RxNorm Concept ID | 1597298-B69729132 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0194 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $9.90 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 90.00% Worth It (13 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) integrating DailyMed SPL (2024-12-03), CMS NADAC ($0.0194/unit), and 13 Zero-PHI patient logs.
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Filter Buscapina (Acetaminophen, Caffeine, Pyrilamine Maleate) community threads and patient logs by age, biological sex, dosage, and treatment duration.