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Acid Reflux, GERD & Upper GI Health • ICD-10-CM K31.6

Gastrointestinal fistula

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM K31.6 • 8 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Gastrointestinal fistula Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Gastrointestinal fistula?

Under Acid Reflux, GERD & Upper GI Health diagnostic criteria (K31.6), workup for Gastrointestinal fistula integrates ambulatory pH-impedance monitoring in Gastrointestinal fistula (K31.6: when refractory) with evidence-graded therapy tailored to Serum Vitamin B12 in Gastrointestinal fistula (K31.6: & Magnesium (chronic) response.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in gerd & stomach, Gastrointestinal fistula (K31.6) involves gastric acid/pepsin mucosal in Gastrointestinal fistula (K31.6: backwash). progression correlates with shifts in Serum Vitamin B12 in Gastrointestinal fistula (K31.6: & Magnesium (chronic) (B12 > 450 pg/mL; Mg >= 2.0 mg/dL (K31.6)).

Common Symptoms & Clinical Signs

  • • Presentation of Gastrointestinal fistula (K31.6): post-meal retrosternal heartburn in Gastrointestinal fistula (K31.6: or sour acid)
  • • Secondary Gastrointestinal fistula clinical sign: epigastric burning, early in Gastrointestinal fistula (K31.6: satiety, or upper-abdominal)
  • • Symptom flares in Gastrointestinal fistula correlating with Serum Vitamin B12 in Gastrointestinal fistula (K31.6: & Magnesium (chronic) deviation outside B12 > 450 pg/mL; Mg >= 2.0 mg/dL (K31.6)
  • • Functional gerd & stomach impact requiring ambulatory pH-impedance monitoring in Gastrointestinal fistula (K31.6: when refractory) evaluation (K31.6)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Gastrointestinal fistula Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code K31.6 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Acid Reflux, GERD & Upper GI Health NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Serum Vitamin B12 in Gastrointestinal fistula (K31.6: & Magnesium (chronic) B12 > 450 pg/mL; Mg >= 2.0 mg/dL (K31.6) Clinical Reference Target Range
Diagnostic / Lab Marker: H. pylori Stool in Gastrointestinal fistula (K31.6: Antigen or Urea) Negative (K31.6) Clinical Reference Target Range
Diagnostic / Lab Marker: Hemoglobin & Serum in Gastrointestinal fistula (K31.6: Ferritin) Ferritin > 50 ng/mL (no occult loss) (K31.6) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Gastrointestinal fistula

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Treatment selection for Gastrointestinal fistula depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Gastrointestinal fistula)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
What the Latest Evidence Really Says About Gastrointestinal side effects of metformin treatment in patients with type 2

The risk of gastrointestinal side effects such as abdominal pain, nausea and diarrhea is higher in type 2 diabetes patients treated with metformin compared to other antidiabetic drugs.

Frontiers in endocrinology • 2022-01-15 • Meta-Analysis
Multi-cohort 92/100 PMID 36187122 ↗
What the Latest Evidence Really Says About Gastrointestinal safety of semaglutide and tirzepatide vs. placebo in obese

Compared to placebo, both Semaglutide and tirzepatide are associated with increased GI adverse outcomes, with most cases being mild.

Annals of Saudi medicine • 2025-01-15 • Meta-Analysis
Multi-cohort 92/100 PMID 40189856 ↗
Can This Approach Help? Inside the Latest Research on Gastrointestinal tolerability and weight reduction associated with tirzepatide in

In this post hoc analysis, GI AEs appeared to contribute slightly to the weight reduction seen with tirzepatide in participants with obesity or overweight with or without T2D.

Diabetes, obesity & metabolism • 2025-04-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 39789843 ↗
Can This Approach Help? Inside the Latest Research on Dupilumab Improves Endoscopic Features in Adult and Adolescent Patients with

At W24, patients showed greater improvement with dupilumab vs placebo in EREFS WOR total score (least squares mean difference [95% confidence interval] -2.17 [-2.59, -1.75], inflammatory subscore -1.65 [-1.96, -1.35], and...

Clinical and translational gastroenterology • 2026-10-01 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 42658181 ↗
Can This Approach Help? Inside the Latest Research on Impact of an oral purified microbiome therapeutic on the gastrointestinal

These findings on the pharmacology of VOS underscore the importance of rapidly restoring key protective functions of the microbiome in patients with recurrent CDI to achieve durable prevention of recurrence, as observed in the...

Nature medicine • 2026-01-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 41491103 ↗
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Gastrointestinal fistula Patient Community & “People Like Me” Threads

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