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Osteoarthritis, Gout & Joint Pain • ICD-10-CM M15.1

Heberden's nodes (with arthropathy)

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM M15.1 • 5 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Heberden's nodes (with arthropathy) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Heberden's nodes (with arthropathy)?

Under Osteoarthritis, Gout & Joint Pain diagnostic criteria (M15.1), workup for Heberden's nodes (with arthropathy) integrates serum urate/inflammatory marker in Heberden's nodes (with arthropathy) (M15.1: profiling) with evidence-graded therapy tailored to hs-CRP & Erythrocyte in Heberden's nodes (with arthropathy) (M15.1: Sedimentation Rate) response.

Pathophysiology, Underlying Causes & Clinical Presentation

In Heberden's nodes (with arthropathy) (M15.1), physiological disruption stems from low-grade synovial metalloproteinase in Heberden's nodes (with arthropathy) (M15.1: release), informing Osteoarthritis, Gout & Joint Pain protocols that track Weight-Bearing Joint Radiograph [Heberden's nodes (with arthropathy) M15.1] (Preserved joint-space width (M15.1)).

Common Symptoms & Clinical Signs

  • • Presentation of Heberden's nodes (with arthropathy) (M15.1): sudden, intensely painful, in Heberden's nodes (with arthropathy) (M15.1: red swollen big-toe)
  • • Secondary Heberden's nodes (with arthropathy) clinical sign: localized tendon or in Heberden's nodes (with arthropathy) (M15.1: bursa tenderness limiting)
  • • Symptom flares in Heberden's nodes (with arthropathy) correlating with hs-CRP & Erythrocyte in Heberden's nodes (with arthropathy) (M15.1: Sedimentation Rate) deviation outside hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M15.1)
  • • Functional arthritis & joints impact requiring serum urate/inflammatory marker in Heberden's nodes (with arthropathy) (M15.1: profiling) evaluation (M15.1)

Heberden's nodes (with arthropathy) Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code M15.1 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Osteoarthritis, Gout & Joint Pain NLM Clinical Tables
Diagnostic / Lab Marker: hs-CRP & Erythrocyte in Heberden's nodes (with arthropathy) (M15.1: Sedimentation Rate) hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M15.1) Clinical Reference Target Range
Diagnostic / Lab Marker: Weight-Bearing Joint Radiograph [Heberden's nodes (with arthropathy) M15.1] Preserved joint-space width (M15.1) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Uric Acid in Heberden's nodes (with arthropathy) (M15.1: (Gout Target)) < 6.0 mg/dL (< 5.0 mg/dL with tophi) (M15.1) Clinical Reference Target Range
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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Heberden's nodes (with arthropathy))

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on A Phase 3, 28-week, multicentre, randomised, gold-standard blind, compared: What a 498-Participant Study Found

LOR was well tolerated despite not meeting the primary endpoint.

Clinical and experimental rheumatology • 2025-05-15 • Phase III Randomized Trial
N = 498 93/100 PMID 39808288 ↗
Can This Approach Help? Inside the Latest Research on Lower injection-site reactions and long-term safety, immunogenicity, and efficacy

YLB113 demonstrated long-term safety and sustained efficacy for up to 96 weeks.

International journal of rheumatic diseases • 2023-01-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 36253032 ↗
Can This Approach Help? Inside the Latest Research on Certolizumab pegol treatment in axial spondyloarthritis mitigates fat lesion

Early and sustained suppression of inflammation mitigates the risk of long-term FL development in the spine in study participants with axSpA evaluated over 4 years.

Rheumatology (Oxford, England) • 2022-07-06 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 34791107 ↗
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