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Osteoarthritis, Gout & Joint Pain • ICD-10-CM M17.3

Hip Replacement

Also known as: Hip arthroplasty, Hip prosthesis

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM M17.3 • 8 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Hip Replacement Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Hip Replacement?

Hip replacement is surgery for people with severe hip damage. The most common cause of damage is osteoarthritis . Osteoarthritis causes pain, swelling, and reduced motion in your joints. It can interfere with your daily activities. If other treatments such as physical therapy, pain medicines, and exercise haven't helped, hip replacement surgery might be an option for you. During a hip replacement operation, the surgeon removes damaged cartilage and bone from your hip joint and replaces them with new, man-made parts.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in arthritis & joints, Hip Replacement (M17.3) involves articular hyaline cartilage in Hip Replacement (M17.3: proteoglycan degradation). Cross-referenced with NIH MeSH (Arthroplasty, Replacement, Hip), progression correlates with shifts in Serum Uric Acid in Hip Replacement (M17.3: (Gout Target)) (< 6.0 mg/dL (< 5.0 mg/dL with tophi) (M17.3)).

Common Symptoms & Clinical Signs

  • • Help your hip joint work better
  • • Improve walking and other movements
  • • Presentation of Hip Replacement (M17.3): activity-related deep aching in Hip Replacement (M17.3: joint pain in)
  • • Secondary Hip Replacement clinical sign: brief morning joint in Hip Replacement (M17.3: stiffness)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Hip Replacement Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code M17.3 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Osteoarthritis, Gout & Joint Pain NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Serum Uric Acid in Hip Replacement (M17.3: (Gout Target)) < 6.0 mg/dL (< 5.0 mg/dL with tophi) (M17.3) Clinical Reference Target Range
Diagnostic / Lab Marker: hs-CRP & Erythrocyte in Hip Replacement (M17.3: Sedimentation Rate) hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M17.3) Clinical Reference Target Range
Diagnostic / Lab Marker: Weight-Bearing Joint Radiograph [Hip Replacement M17.3] Preserved joint-space width (M17.3) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Hip Replacement

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Accrufer (Ferric Maltol) Accrufer • RxCUI 2539949 Parenteral Iron Replacement 78% $9.8880 $ 640.00 /mo
Magnesium Sulfate Natural Epsom Salt, Epsom Salt • RxCUI 829762 Calculi Dissolution Agent 87% $0.0039 $ 8.66 /mo
Velaglucerase Alfa Vpriv • RxCUI 901808 Hydrolytic Lysosomal Glucocerebroside-specific Enzyme 90% $1.5000 $ 69.25 /mo
Monsels Solution (Ferric Subsulfate) Monsels Solution • RxCUI RXN-B48783112 Parenteral Iron Replacement 92% $6.0970 $ 447.48 /mo
Ferumoxytol Ferabright, Feraheme • RxCUI RXN-24338310-2314 Parenteral Iron Replacement 93% $2.5000 $ 109.75 /mo
Levothyroxine, Liothyronine Np Thyroid 30, Np Thyroid 15 • RxCUI 313387 l-Thyroxine 94% $0.5134 $ 29.29 /mo
Vpriv (Velaglucerase Alfa) Vpriv • RxCUI 901812 Hydrolytic Lysosomal Glucocerebroside-specific Enzyme 94% $2.7500 $ 206.50 /mo
Ferabright (Ferumoxytol) Ferabright • RxCUI RXN-B24338310 Parenteral Iron Replacement 83% $1.1400 $ 90.58 /mo
Testosterone Vogelxo, Natesto Nasal Gel • RxCUI 1599949 Androgen 74% $0.5076 $ 29.06 /mo
Venofer (Iron Sucrose) Venofer (Iron Sucrose) Generic • RxCUI RXN-516621568-2366 Parenteral Iron Replacement 90% $12.2067 $ 185.00 /mo
Ferric Subsulfate Monsels Solution • RxCUI RXN-48783112-2762 Parenteral Iron Replacement 93% $6.0970 $ 185.00 /mo
Testosterone Cypionate, Alcohol Testone Cik • RxCUI 797544 FDA Prescription Therapeutic Agent 86% $2.1035 $ 93.69 /mo
Injectafer (Ferric Carboxymaltose Injection) Injectafer • RxCUI RXN-B05170650 Parenteral Iron Replacement 81% $6.0970 $ 447.48 /mo
Infed (Iron Dextran) Infed • RxCUI 311144 Parenteral Iron Replacement 74% $18.0002 $ 640.00 /mo
Ferrlecit (Sodium Ferric Gluconate Complex) Ferrlecit • RxCUI 261123 Parenteral Iron Replacement 82% $6.0970 $ 447.48 /mo
Fludrocortisone Acetate Florinef • RxCUI 313979 Pain & Inflammation Agent 77% $0.3098 $ 12.45 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Hip Replacement)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Association between testosterone replacement therapy and heart and blood vessel: What a 11,502-Participant Study Found

Our analysis indicates that for patients with hypogonadism, testosterone replacement therapy does not increase the CVD risk and all-cause mortality.

Progress in cardiovascular diseases • 2024-01-15 • Meta-Analysis
N = 11,502 99/100 PMID 38589271 ↗
New Insights on Effect of testosterone replacement therapy on lower urinary tract: What a 2,453-Participant Study Found

The results demonstrate that TRT does not worsen LUTS regardless of the administration route.

Journal of evidence-based medicine • 2024-09-15 • Meta-Analysis
N = 2,453 99/100 PMID 39004879 ↗
New Insights on Long-Term heart and blood vessel Safety of Testosterone-Replacement Therapy in: What a 9,280-Participant Study Found

In men with low to low-normal testosterone, aged 40 and above, TRT did not increase all-cause mortality, heart and blood vessel mortality, stroke, or heart attack, but increased the incidence of cardiac arrhythmias.

American journal of cardiovascular drugs : drugs, devices, and other interventions • 2025-11-15 • Meta-Analysis
N = 9,280 99/100 PMID 40694252 ↗
New Insights on Effect of testosterone replacement therapy on fracture risk in hypogonadal: What a 2,711-Participant Study Found

TRT is associated with an increased incidence of predominantly non-major fractures, while the risk of major osteoporotic fractures, including hip and vertebral fractures, was not increased.

Maturitas • 2026-06-15 • Meta-Analysis
N = 2,711 99/100 PMID 42066666 ↗
New Insights on Efficacy of testosterone replacement therapy for treating metabolic disturbances: What a 1,373-Participant Study Found

This study demonstrated greater improvement in metabolic profiles for patients given TRT versus placebo.

International urology and nephrology • 2021-09-15 • Meta-Analysis
N = 1,373 99/100 PMID 34089171 ↗
Zero-PHI Patient Support & Cohort Discussions

Hip Replacement Patient Community & “People Like Me” Threads

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