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PCOS, Endometriosis & Gynecologic Health • ICD-10-CM N81.5

Hysterectomy

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM N81.5 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Hysterectomy Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Hysterectomy?

What is a hysterectomy? A hysterectomy is surgery to remove the uterus (womb). The uterus is the place where a fetus grows during pregnancy. A hysterectomy treats problems like heavy bleeding, pain, or cancer in the uterus. After a hysterectomy, you no longer have menstrual periods and can't become pregnant. Sometimes the surgery also removes the ovaries and fallopian tubes. If you have both ovaries taken out, menopause symptoms will usually begin. What conditions does a hysterectomy treat? Hysterectomy is a major surgery. Your health care provider may suggest other treatment options first.

Pathophysiology, Underlying Causes & Clinical Presentation

In Hysterectomy (N81.5), physiological disruption stems from reduced hepatic SHBG in Hysterectomy (N81.5: (in PCOS)), Cross-referenced with NIH MeSH (Hysterectomy), informing PCOS, Endometriosis & Gynecologic Health protocols that track LH, FSH & in Hysterectomy (N81.5: Prolactin) (Normal ovulatory endocrine axis (N81.5)).

Common Symptoms & Clinical Signs

  • • Fibroids , if you are near or past menopause, have large fibroids or very heavy bleeding
  • • Endometriosis , that hasn't been cured by medicine or surgery
  • • Presentation of Hysterectomy (N81.5): hyperandrogenic acne along in Hysterectomy (N81.5: the jawline, hirsutism,)
  • • Secondary Hysterectomy clinical sign: pelvic pressure, bloating, in Hysterectomy (N81.5: or pain radiating)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Hysterectomy Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code N81.5 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub PCOS, Endometriosis & Gynecologic Health NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: CBC & Serum in Hysterectomy (N81.5: Ferritin (heavy bleeding)) Ferritin > 50 ng/mL (N81.5) Clinical Reference Target Range
Diagnostic / Lab Marker: LH, FSH & in Hysterectomy (N81.5: Prolactin) Normal ovulatory endocrine axis (N81.5) Clinical Reference Target Range
Diagnostic / Lab Marker: Free & Total in Hysterectomy (N81.5: Testosterone + SHBG) Sex-specific physiological range (N81.5) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Hysterectomy

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Treatment selection for Hysterectomy depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Hysterectomy)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on [Comment] Preserving the uterus: an effective dual therapy to avoid

Endometrial ablation offers an effective, uterus-sparing alternative for women who do not desire future childbearing, with lower perioperative morbidity and faster recovery than hysterectomy.1–3 However, the durability of this...

The Lancet • 2026-10-21 • Peer-Reviewed Journal (Clinical Trials)
Multi-cohort 95/100 PMID LANCET-2824242815 ↗
Can This Approach Help? Inside the Latest Research on Benefits and safety of co-crystal of tramadol-celecoxib (CTC) in acute

Although the study did not meet its primary endpoint, CTC 200 mg showed a clinically relevant improvement in overall.

European journal of pain (London, England) • 2022-11-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 35974668 ↗
Can This Approach Help? Inside the Latest Research on Investigating the effects of estradiol or estradiol/progesterone treatment on

The two hormones, however, had no effects on mood, well-being, menopausal symptoms, sleep quality and depressive symptoms.

Neuropsychobiology • 2005-01-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 15942259 ↗
New Insights on Chemoradiotherapy With or Without Simultaneous Integrated Boost for Cervical: What a 466-Participant Study Found

A total of 466 patients with cervical cancer presenting with FT or OFT stromal invasion after radical hysterectomy were randomized (233 in non-SIB radiotherapy group: median age, 53 years [IQR, 46-59 years]; 233 in SIB...

JAMA network open • 2025-09-02 • Phase III Randomized Trial
N = 466 87/100 PMID 40971156 ↗
Can This Approach Help? Inside the Latest Research on Comparative outcomes of simple versus radical hysterectomy in patients with and

There were similar recurrence and survival outcomes but less morbidity from SH compared to RH in patients with and without very low-risk early-stage cervical cancer from the SHAPE trial.

Gynecologic oncology • 2026-02-15 • Phase III Randomized Trial
N = 107 82/100 PMID 41520567 ↗
Zero-PHI Patient Support & Cohort Discussions

Hysterectomy Patient Community & “People Like Me” Threads

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