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PCOS, Endometriosis & Gynecologic Health • ICD-10-CM C56.9

Ovarian Cancer

Also known as: Ovary, Ovaries, Ovarian, Fibroid, Leiomyoma

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM C56.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Ovarian Cancer Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Ovarian Cancer?

What is ovarian cancer? Cancer is a disease in which abnormal cells in the body grow out of control and form a tumor. Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. The ovaries are a pair of female reproductive glands that make eggs and female hormones . What are the types of ovarian cancer? There are a few different types of ovarian cancer. The most common type is epithelial cancer. It begins in the cells that cover the ovary. There are also two related types of epithelial cancer that can spread to the ovaries: Fallopian tube cancer forms in the tissue lining a fallopian tube.

Pathophysiology, Underlying Causes & Clinical Presentation

Tissue-level etiology in Ovarian Cancer (C56.9) features reduced hepatic SHBG in Ovarian Cancer (C56.9: (in PCOS)). Cross-referenced with NIH MeSH (Peritoneal Neoplasms, Fallopian Tube Neoplasms), therapeutic stabilization in ob/gyn & pcos is verified against LH, FSH & in Ovarian Cancer (C56.9: Prolactin).

Common Symptoms & Clinical Signs

  • • Have a family history of ovarian cancer in a mother, aunt, grandmother, or sister
  • • Have inherited changes in the BRCA1 or BRCA2 genes
  • • Presentation of Ovarian Cancer (C56.9): hyperandrogenic acne along in Ovarian Cancer (C56.9: the jawline, hirsutism,)
  • • Secondary Ovarian Cancer clinical sign: pelvic pressure, bloating, in Ovarian Cancer (C56.9: or pain radiating)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Ovarian Cancer Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code C56.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub PCOS, Endometriosis & Gynecologic Health NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: CBC & Serum in Ovarian Cancer (C56.9: Ferritin (heavy bleeding)) Ferritin > 50 ng/mL (C56.9) Clinical Reference Target Range
Diagnostic / Lab Marker: LH, FSH & in Ovarian Cancer (C56.9: Prolactin) Normal ovulatory endocrine axis (C56.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Free & Total in Ovarian Cancer (C56.9: Testosterone + SHBG) Sex-specific physiological range (C56.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Ovarian Cancer

Check Drug Interactions →
Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Carboplatin Kyxata • RxCUI 597195 Platinum-based Drug 81% $0.6200 $ 33.61 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Ovarian Cancer)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Veliparib concomitant with first-line chemotherapy and as maintenance therapy in: What a 1,140-Participant Study Found

No OS or DRS benefit of addition of veliparib to platinum-based chemotherapy and continued as maintenance therapy was detected in this study, despite an observed.

European journal of cancer (Oxford, England : 1990) • 2025-07-25 • Phase III Randomized Trial
N = 1,140 96/100 PMID 40561681 ↗
New Insights on Impact of subclinical hypothyroidism on core reproductive hormones and ovarian: What a 3,114-Participant Study Found

Current evidence shows no significant differences in FSH, LH, estradiol, or total testosterone levels between SCH and euthyroid PCOS controls, while the evidence for prolactin.

Frontiers in endocrinology • 2026-01-15 • Meta-Analysis
N = 3,114 94/100 PMID 42798498 ↗
New Insights on Reproductive hormone characteristics of obese Chinese patients with polycystic: What a 4,554-Participant Study Found

Conversely, they exhibited significantly higher testosterone (T) ( p = 0.001) levels.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology • 2025-12-15 • Meta-Analysis
N = 4,554 94/100 PMID 40287875 ↗
New Insights on Selected side effects during the 12-week induction period of a phase III trial of: What a 690-Participant Study Found

Vunakizumab is not significantly associated with the occurrence of any AE or most selected AE categories in patients with moderate-to-severe plaque psoriasis skin flare-ups skin flare-ups, whereas vunakizumab is associated...

Frontiers in immunology • 2026-01-15 • Phase III Randomized Trial
N = 690 93/100 PMID 42952621 ↗
New Insights on Phase III Randomized Trial of Maintenance Taxanes Versus Surveillance in Women: What a 1,157-Participant Study Found

Maintenance therapy with P and PP did not improve OS among patients with newly diagnosed O/tubal/peritoneal cancer, but may modestly increase PFS.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2022-12-10 • Phase III Randomized Trial
N = 1,157 90/100 PMID 35759733 ↗
Zero-PHI Patient Support & Cohort Discussions

Ovarian Cancer Patient Community & “People Like Me” Threads

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