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Thyroid, Adrenal & Endocrine Disorders • ICD-10-CM E01.2

Iodine-deficiency related (endemic) goiter

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E01.2 • 6 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Iodine-deficiency related (endemic) goiter Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Iodine-deficiency related (endemic) goiter?

Iodine-deficiency related (endemic) goiter is an ICD-10-CM indexed diagnosis (E01.2) within Thyroid, Adrenal & Endocrine Disorders. Clinical evaluation centers on autoimmune antibody titers [Iodine-deficiency related (endemic) goiter E01.2] alongside serial Thyroid-Stimulating Hormone (TSH) [Iodine-deficiency related (endemic) goiter E01.2] tracking (0.8 – 2.5 mIU/L (E01.2)) to guide individualized care.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in thyroid & endocrine, Iodine-deficiency related (endemic) goiter (E01.2) involves altered peripheral hormone in Iodine-deficiency related (endemic) goiter (E01.2: receptor transcription). progression correlates with shifts in Thyroid-Stimulating Hormone (TSH) [Iodine-deficiency related (endemic) goiter E01.2] (0.8 – 2.5 mIU/L (E01.2)).

Common Symptoms & Clinical Signs

  • • Presentation of Iodine-deficiency related (endemic) goiter (E01.2): unexplained shifts in in Iodine-deficiency related (endemic) goiter (E01.2: cold/heat tolerance, basal)
  • • Secondary Iodine-deficiency related (endemic) goiter clinical sign: persistent fatigue, sluggish in Iodine-deficiency related (endemic) goiter (E01.2: morning waking, or)
  • • Symptom flares in Iodine-deficiency related (endemic) goiter correlating with Thyroid-Stimulating Hormone (TSH) [Iodine-deficiency related (endemic) goiter E01.2] deviation outside 0.8 – 2.5 mIU/L (E01.2)
  • • Functional thyroid & endocrine impact requiring autoimmune antibody titers [Iodine-deficiency related (endemic) goiter E01.2] evaluation (E01.2)

Iodine-deficiency related (endemic) goiter Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E01.2 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Thyroid, Adrenal & Endocrine Disorders NLM Clinical Tables
Diagnostic / Lab Marker: Thyroid-Stimulating Hormone (TSH) [Iodine-deficiency related (endemic) goiter E01.2] 0.8 – 2.5 mIU/L (E01.2) Clinical Reference Target Range
Diagnostic / Lab Marker: Free Thyroxine (Free in Iodine-deficiency related (endemic) goiter (E01.2: T4) & Free) FT4 1.1–1.6 ng/dL; FT3 3.0–4.0 pg/mL (E01.2) Clinical Reference Target Range
Diagnostic / Lab Marker: Morning Serum Cortisol in Iodine-deficiency related (endemic) goiter (E01.2: (8 AM)) 10 – 18 mcg/dL (E01.2) Clinical Reference Target Range
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Treatment selection for Iodine-deficiency related (endemic) goiter depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Iodine-deficiency related (endemic) goiter)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Menopausal hormone formulations on pituitary-ovarian regulatory

Two common HT regimens differentially alter pituitary-ovarian hormone levels, altering feedback cycles and interhormonal associations in recently menopausal women.

American journal of physiology. Regulatory, integrative and comparative physiology • 2019-12-01 • Randomized Controlled Trial
N = 146 88/100 PMID 31663769 ↗
New Insights on Effectiveness of Intrarectal Povidone-iodine Cleansing Plus Formalin Disinfection: What a 633-Participant Study Found

Intrarectal povidone-iodine cleansing plus formalin disinfection of the biopsy needle tip was associated with a reduction in infectious complications after transrectal prostate biopsy.

The Journal of urology • 2022-12-15 • Phase III Randomized Trial
N = 633 87/100 PMID 36006040 ↗
Can This Approach Help? Inside the Latest Research on Trimodality Therapy With Iodine-125 Brachytherapy, External Beam Radiation

Both treatment arms showed similar efficacy among selected populations with high-risk features.

International journal of radiation oncology, biology, physics • 2024-02-01 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 37802225 ↗
Can This Approach Help? Inside the Latest Research on Do Statins Affect Thyroid Volume and Nodule Size in Patients with high

Our results suggest an association between rosuvastatin treatment and smaller thyroid volume and maximum nodule diameter; this could be attributable to the antiproliferative effects of statin therapy on the thyroid.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre • 2018-01-15 • Randomized Controlled Trial
Multi-cohort 82/100 PMID 29402848 ↗
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