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Thyroid, Adrenal & Endocrine Disorders • ICD-10-CM R61

Sweat

Also known as: Perspiration, Bromhidrosis

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM R61 • 6 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Sweat Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Sweat?

Sweat is a clear, salty liquid produced by glands in your skin. Sweating is how your body cools itself. You sweat mainly under your arms and on your feet and palms. When sweat mixes with bacteria on your skin, it can cause a smell. Bathing regularly and using antiperspirants or deodorants can help control the odor. Sweating a lot is normal when it is hot or when you exercise, are anxious, or have a fever. It also happens during menopause. If you often sweat too much, it's called hyperhidrosis. Causes include thyroid or nervous system disorders, low blood sugar, or another health problem.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Sweat (R61) center on hypothalamic-pituitary-endocrine feedback dysregulation [Sweat R61]. Cross-referenced with NIH MeSH (Sweat), targeted thyroid & endocrine interventions aim to normalize Thyroid-Stimulating Hormone (TSH) [Sweat R61].

Common Symptoms & Clinical Signs

  • • Presentation of Sweat (R61): unexplained shifts in in Sweat (R61: cold/heat tolerance, basal)
  • • Secondary Sweat clinical sign: persistent fatigue, sluggish in Sweat (R61: morning waking, or)
  • • Symptom flares in Sweat correlating with Thyroid-Stimulating Hormone (TSH) [Sweat R61] deviation outside 0.8 – 2.5 mIU/L (R61)
  • • Functional thyroid & endocrine impact requiring electrolyte-mineral balance monitoring [Sweat R61] evaluation (R61)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Sweat Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code R61 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Thyroid, Adrenal & Endocrine Disorders NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Thyroid-Stimulating Hormone (TSH) [Sweat R61] 0.8 – 2.5 mIU/L (R61) Clinical Reference Target Range
Diagnostic / Lab Marker: Free Thyroxine (Free in Sweat (R61: T4) & Free) FT4 1.1–1.6 ng/dL; FT3 3.0–4.0 pg/mL (R61) Clinical Reference Target Range
Diagnostic / Lab Marker: Morning Serum Cortisol in Sweat (R61: (8 AM)) 10 – 18 mcg/dL (R61) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Sweat

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Treatment selection for Sweat depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Sweat)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on A novel lotion formulation of 20% oxybutynin hydrochloride for the treatment of

In patients with PPHH, 20% OL is superior to placebo in reducing palmar sweat volume.

Journal of the American Academy of Dermatology • 2023-07-15 • Phase III Randomized Trial
N = 144 88/100 PMID 36990320 ↗
Can This Approach Help? Inside the Latest Research on Oral micronized progesterone for perimenopausal night sweats and hot flushes a

Perimenopausal night sweats ± hot flushes are variable; this RCT was underpowered but could not exclude a minimal clinically important VMS benefit.

Scientific reports • 2023-06-05 • Phase III Randomized Trial
N = 189 88/100 PMID 37277418 ↗
Can This Approach Help? Inside the Latest Research on A multicentre randomised controlled trial of a guided self-help cognitive

ISRCTN reference 58720120 .

Trials • 2023-07-10 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 37430353 ↗
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