✓ Translated by DotMD AI Clinical Council Source: Trials • Phase III Randomized Trial
Verify Primary Source: NIH PubMed PMID #37430353 ↗

Phase III Randomized Trial: A multicentre randomised controlled trial of a guided self-help cognitive behavioural therapy to MANage the impact of hot flushes and night sweats in patients with prostate CANcer undergoing androgen deprivation therapy (MANCAN2)

Original Paper Title: “A multicentre randomised controlled trial of a guided self-help cognitive behavioural therapy to MANage the impact of hot flushes and night sweats in patients with prostate CANcer undergoing androgen deprivation therapy (MANCAN2)”

Elena Rostova (AI Quant) Rigor Score
82 / 100
Sample Size (Participants)
Systematic Review
Evidence Classification
Phase III Randomized Trial
Sarah Jenkins, RN (AI Plain-English Editor) • Key Takeaways
  • ISRCTN reference 58720120 . Registered 13 December 2022.
  • Study Design & Sample: Phase III Randomized Trial published in Trials (Multi-cohort synthesis).
  • Biostatistical Rigor Score: 82/100 audited by Elena Rostova (AI Biostatistician & openFDA Quant).

What the Study Found (In Plain English)

Published in Trials (2023), this phase iii randomized trial evaluating human clinical outcomes investigated: Androgen deprivation therapy (ADT) is prescribed to almost half of all men diagnosed with prostate cancer. Key clinical takeaway: ISRCTN reference 58720120 . Registered 13 December 2022.

Dr. Lin (AI Evidence Lead): Statistical Endpoints & Numbers

Primary Endpoint & Quantitative Summary (Trials, 2023-07-10; Phase III Randomized Trial; Rigor 82/100): ISRCTN reference 58720120 . Registered 13 December 2022.

Study Limitations & Caveats Before You Act

Clinical trials evaluate specific inclusion/exclusion cohorts under protocol-controlled conditions (Phase III Randomized Trial). Individual response, hepatic/renal clearance, CYP450 drug interactions, and baseline comorbidities vary; verify applicability with a board-certified physician before modifying any prescription or supplement regimen.

Related DotMD Clinical Hubs & Price Ledgers

Rx: zinc-cold-therapy-zinc-gluconate → Rx: ultra-zinc-cold-therapy-zincum-gluconicum → Rx: quality-choice-effervescent-cold-relief-plus-aspirin-chlorpheniramine → Rx: quality-choice-pain-relief-powder-aspirin-and-caffeine → Condition: prostate-cancer → Condition: sweat →
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