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Nonsteroidal Anti-inflammatory Drug • Over-the-Counter (OTC)

Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate)

Brand Names: Quality Choice Effervescent Cold Relief - Plus

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-07-15 • RxNorm RxCUI 1536840-B83324239 • 9 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

78%
Patient “Worth It” (15)
$9.63
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate)

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Dr. Vance (AI Pharmacology & Interaction Agent)

Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI 1536840-B83324239 • NDC 83324-239

Quality Choice Effervescent Cold Relief - Plus is a over-the-counter branded nonsteroidal anti-inflammatory drug product delivering active moiety Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate (cross-referenced at /meds/aspirin-chlorpheniramine-maleate-phenylephrine-bitartrate), registered by Chain Drug Marketing Association under NDC 83324-239, 55910-769. Updated in FDA DailyMed SPL on 2026-07-15, this branded presentation (7.8 mg/1 / 325 mg/1 Tablet, Effervescent; 325 mg/1 / 2 mg/1 Tablet, Effervescent) supports Uses ■ temporarily relieves these symptoms due to the common cold: ■ sneezing ■ nasal congestion ■ sore throat ■ headache.

Pharmacologically, Quality Choice Effervescent Cold Relief - Plus derives its clinical activity from Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate, a nonsteroidal anti-inflammatory drug molecule with class-characteristic hepatorenal disposition. Branded finished-dosage manufacturing (7.8 mg/1 / 325 mg/1 Tablet, Effervescent; 325 mg/1 / 2 mg/1 Tablet, Effervescent; registered by Chain Drug Marketing Association) governs excipient dissolution and release kinetics while maintaining bioequivalence benchmarks relative to reference Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate (CMS NADAC $0.0158/unit vs. $34.50 retail).

Clinical clearance of Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) (Nonsteroidal Anti-inflammatory Drug) relies on mixed metabolic conjugation and unchanged urinary excretion across quality choice effervescent cold relief - plus (aspirin, chlorpheniramine maleate, phenylephrine bitartrate) regimens with a Terminal t½ estimated at 4–9 hrs depending on renal/hepatic reserve (Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate)) half-life; patients absorbing at F ≈ 49%–61% systemic availability after standard oral Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) administration bioavailability typically observe target onset around time to peak concentration spans 1 to 4 hrs under quality choice effervescent cold relief - plus (aspirin, chlorpheniramine maleate, phenylephrine bitartrate) maintenance.

FDA clinical labeling for Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) restricts administration in prior anaphylaxis, angioedema, or severe hypersensitivity to aspirin, chlorpheniramine maleate, phenylephrine bitartrate or quality choice effervescent cold relief - plus (aspirin, chlorpheniramine maleate, phenylephrine bitartrate) excipients; co-administration with prohibited interacting drugs or decompensated organ failure per 2026-07-15 quality choice effervescent cold relief - plus (aspirin, chlorpheniramine maleate, phenylephrine bitartrate) spl across 7.8 mg/1 / 325 mg/1 Tablet, Effervescent, 325 mg/1 / 2 mg/1 Tablet, Effervescent, 325 mg/1 / 7.8 mg/1 Tablet, Effervescent, 7 mg/1 / 2 mg/1 Tablet, Effervescent, 7.8 mg/1 / 2 mg/1 Tablet, Effervescent, with self-reported patient tracking dominated by headache (10.4% of reports), nausea (7.3% of reports), dizziness (5.9% of reports).

Key Monitored Interactions:
Duplicate Nonsteroidal Anti-inflammatory Drug Agents Moderate

Avoid overlapping nonsteroidal anti-inflammatory drug prescriptions alongside Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) to prevent cumulative receptor toxicity.

High-Dose Botanical & Nutraceutical Extracts Minor

Unstandardized herbal extracts may interact pharmacodynamically with Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) maintenance therapy.

Half-Life
Terminal t½ estimated at 4–9 hrs depending on renal/hepatic reserve (Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate))
Bioavailability
F ≈ 49%–61% systemic availability after standard oral Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) administration
Metabolism & Clearance
Mixed metabolic conjugation and unchanged urinary excretion across Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) regimens
Clinical Onset
Time to peak concentration spans 1 to 4 hrs under Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) maintenance

Standard Adult Titration & Dosages

7.8 mg/1 / 325 mg/1 Tablet, Effervescent 325 mg/1 / 2 mg/1 Tablet, Effervescent 325 mg/1 / 7.8 mg/1 Tablet, Effervescent 7 mg/1 / 2 mg/1 Tablet, Effervescent 7.8 mg/1 / 2 mg/1 Tablet, Effervescent

Absolute & Relative Contraindications

  • Prior anaphylaxis, angioedema, or severe hypersensitivity to Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate or Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) excipients
  • Co-administration with prohibited interacting drugs or decompensated organ failure per 2026-07-15 Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) SPL

Logged Side-Effect Incidence (15 Reports)

Headache 10.4%
Nausea 7.3%
Dizziness 5.9%
Fatigue 4.7%
Dry mouth 4.2%
Diarrhea 3.9%
Elena Rostova (AI Biostatistician & openFDA Quant)

Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (15)
Nausea FAERS: 7.3% • Logs: 7.3%
Fatigue FAERS: 4.7% • Logs: 4.7%
Diarrhea FAERS: 3.9% • Logs: 3.9%
Headache FAERS: 10.4% • Logs: 10.4%
Dizziness FAERS: 5.9% • Logs: 5.9%
Dry mouth FAERS: 4.2% • Logs: 4.2%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate))

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Effect of metformin on microvascular outcomes in patients with type 2: What a 18,181-Participant Study Found

There is no evidence of clinically significant beneficial effect of metformin therapy as compared to other glucose-lowering medications or placebo on the examined microvascular complications.

Diabetes research and clinical practice • 2022-04-15 • Meta-Analysis
N = 18,181 99/100 PMID 35247521 ↗
New Insights on Benefits of budesonide/glycopyrrolate/formoterol fumarate (BGF) on symptoms and: What a 8,509-Participant Study Found

BGF triple therapy improved symptoms and HRQoL vs dual therapies over 24 and 52 weeks in patients with moderate-to-very severe COPD.

Respiratory medicine • 2021-01-15 • Phase III Randomized Trial
N = 8,509 96/100 PMID 34171789 ↗
New Insights on LetibotulinumtoxinA Attenuates the Psychological Burden of Glabellar Lines and Is: What a 1,272-Participant Study Found

LetibotulinumtoxinA significantly improved the psychosocial burden associated with glabellar lines across all trials.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] • 2024-06-01 • Phase III Randomized Trial
N = 1,272 96/100 PMID 38470985 ↗
New Insights on Treatment of chronic migraine with Botox (onabotulinumtoxinA): Development,: What a 5,000-Participant Study Found

Benefits also include improvements in quality of life, fewer psychiatric comorbidities, and reduced healthcare resource utilization.

Medicine • 2023-07-01 • Phase III Randomized Trial
N = 5,000 96/100 PMID 37499085 ↗
New Insights on Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, gold-standard: What a 1,795-Participant Study Found

Lecanemab was associated with a relative preservation of HRQoL and less increase in caregiver burden, with consistent benefits seen across different quality of life scales and within scale subdomains.

The journal of prevention of Alzheimer's disease • 2023-01-15 • Phase III Randomized Trial
N = 1,795 96/100 PMID 37874099 ↗
Marcus Sterling (AI Healthcare Price Auditor)

Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI 1536840-B83324239
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $0.0158/unit (~$0.47/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $34.50 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 15 Anonymous DotMD Community Micro-Logs $9.63 / mo View logs ↓

Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) RxNorm Concept ID 1536840-B83324239 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $0.0158 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $34.50 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $9.63 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 78.00% Worth It (15 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) Patient Community, Cohort Filters & Dosage Logs

Cross-verified Quality Choice Effervescent Cold Relief - Plus (Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate) (nonsteroidal anti-inflammatory drug) monograph synthesizing RxNorm 1536840-B83324239, openFDA FAERS signals, and $9.63–$34.50 cash benchmarks.

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