Joint pain (arthralgia)
Also known as: Arthralgia
Methodology & AI Transparency ⓘ
Joint pain (arthralgia) Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Cataloged under federal diagnostic code M25.50 in Arthritis & Joints, Joint pain (arthralgia) (also termed Arthralgia) requires urate-lowering titration [Joint pain (arthralgia) M25.50] so specialists can calibrate treatment intensity against Weight-Bearing Joint Radiograph [Joint pain (arthralgia) M25.50] benchmarks.
- 2 Real-world patient consensus: Clinical coding for Joint pain (arthralgia) uses ICD-10 M25.50 across Arthritis & Joints specialty care.
- 3 Typical cash cost range: Differential triage of Joint pain (arthralgia) (M25.50) utilizes urate-lowering titration [Joint pain (arthralgia) M25.50].
- 4 Top reported side effects / signs: Follow-up benchmark in Joint pain (arthralgia): maintaining Weight-Bearing Joint Radiograph [Joint pain (arthralgia) M25.50] within Preserved joint-space width (M25.50).
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What Is Joint pain (arthralgia)?
Cataloged under federal diagnostic code M25.50 in Arthritis & Joints, Joint pain (arthralgia) (also termed Arthralgia) requires urate-lowering titration [Joint pain (arthralgia) M25.50] so specialists can calibrate treatment intensity against Weight-Bearing Joint Radiograph [Joint pain (arthralgia) M25.50] benchmarks.
Pathophysiology, Underlying Causes & Clinical Presentation
Tissue-level etiology in Joint pain (arthralgia) (M25.50) features monosodium urate or in Joint pain (arthralgia) (M25.50: calcium pyrophosphate crystal). therapeutic stabilization in arthritis & joints is verified against Serum Uric Acid in Joint pain (arthralgia) (M25.50: (Gout Target)).
Common Symptoms & Clinical Signs
- • Presentation of Joint pain (arthralgia) (M25.50): localized tendon or in Joint pain (arthralgia) (M25.50: bursa tenderness limiting)
- • Secondary Joint pain (arthralgia) clinical sign: activity-related deep aching in Joint pain (arthralgia) (M25.50: joint pain in)
- • Symptom flares in Joint pain (arthralgia) correlating with Weight-Bearing Joint Radiograph [Joint pain (arthralgia) M25.50] deviation outside Preserved joint-space width (M25.50)
- • Functional arthritis & joints impact requiring urate-lowering titration [Joint pain (arthralgia) M25.50] evaluation (M25.50)
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Joint pain (arthralgia) Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | M25.50 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | Osteoarthritis, Gout & Joint Pain | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: Weight-Bearing Joint Radiograph [Joint pain (arthralgia) M25.50] | Preserved joint-space width (M25.50) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Serum Uric Acid in Joint pain (arthralgia) (M25.50: (Gout Target)) | < 6.0 mg/dL (< 5.0 mg/dL with tophi) (M25.50) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: hs-CRP & Erythrocyte in Joint pain (arthralgia) (M25.50: Sedimentation Rate) | hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M25.50) | Clinical Reference Target Range |
FDA-Monographed Medications & Public Cash Price Reference for Joint pain (arthralgia)
| Medication | Pharmacologic Class | Patient Worth-It | CMS NADAC / Unit | Typical Lowest Cash |
|---|---|---|---|---|
| Debbies Down and Dirty Deep Tissue Joint and Muscle (Menthol) Debbies Down and Dirty Deep Tissue Joint and Muscle • RxCUI 253020 | Calculi Dissolution Agent | 89% | $0.8804 | $ 71.89 /mo |
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Joint pain (arthralgia))
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Incremental cholesterol reduction with ezetimibe/simvastatin, atorvastatin and: What a 263-Participant Study Found Approximately 45% of. International journal of clinical practice • 2010-07-15 • Randomized Controlled Trial | N = 263 | 93/100 | PMID 20487050 ↗ |
| New Insights on Benefits and safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A: What a 451-Participant Study Found Dotinurad 4 mg/day was superior to febuxostat 40 mg/day in achieving serum urate levels ≤6.0 mg/dL at week 24 and was well tolerated in Chinese patients with gout. Arthritis & rheumatology (Hoboken, N.J.) • 2025-12-15 • Phase III Randomized Trial | N = 451 | 93/100 | PMID 40417858 ↗ |
| New Insights on A Phase 3, 28-week, multicentre, randomised, gold-standard blind, compared: What a 498-Participant Study Found LOR was well tolerated despite not meeting the primary endpoint. Clinical and experimental rheumatology • 2025-05-15 • Phase III Randomized Trial | N = 498 | 93/100 | PMID 39808288 ↗ |
| Can This Approach Help? Inside the Latest Research on Effect of ivarmacitinib on swelling and tenderness in small and large joints and Ivarmacitinib 4 mg and 8 mg groups showed greater reductions in bone erosion and synovitis scores under MRI scanning from baseline to W24 versus the placebo group. Naunyn-Schmiedeberg's archives of pharmacology • 2026-05-15 • Phase III Randomized Trial | N = 189 | 88/100 | PMID 41741728 ↗ |
| Can This Approach Help? Inside the Latest Research on Established ASAS definition and preliminary proposed data-driven cut-offs for The purpose of this paper is to evaluate patient characteristics and treatment outcomes in patients with nonradiographic axial spondyloarthritis (nr-axSpA) eligible for a clinical trial based on the 2009 established Assessment... Annals of the rheumatic diseases • 2026-09-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 42350183 ↗ |
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