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Weight Management & Metabolic Syndrome • ICD-10-CM E65.2

Obesity in Children

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E65.2 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Obesity in Children Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Obesity in Children?

Obesity means having too much body fat. It is different from being overweight, which means weighing too much. Both terms mean that a person's weight is greater than what's considered healthy for his or her height. Children grow at different rates, so it isn't always easy to know when a child has obesity or is overweight. Ask your health care provider to check whether your child's weight and height are in a healthy range. If a weight-loss program is necessary, involve the whole family in healthy habits so your child doesn't feel singled out.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Obesity in Children (E65.2) center on hypothalamic arcuate nucleus in Obesity in Children (E65.2: leptin resistance). Cross-referenced with NIH MeSH (Pediatric Obesity, Obesity), targeted weight & metabolism interventions aim to normalize ALT & Fasting in Obesity in Children (E65.2: Triglycerides).

Common Symptoms & Clinical Signs

  • • Serving more fruits and vegetables
  • • Buying fewer soft drinks and high-fat, high-calorie snack foods
  • • Presentation of Obesity in Children (E65.2): persistent hunger signaling [Obesity in Children E65.2]
  • • Secondary Obesity in Children clinical sign: co-existing blood pressure, in Obesity in Children (E65.2: triglyceride, or fasting)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Obesity in Children Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E65.2 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Weight Management & Metabolic Syndrome NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: ALT & Fasting in Obesity in Children (E65.2: Triglycerides) ALT < 25 U/L; TG < 100 mg/dL (E65.2) Clinical Reference Target Range
Diagnostic / Lab Marker: DEXA Visceral Adipose in Obesity in Children (E65.2: Tissue (VAT)) < 1.0 lb (< 100 cm2) (E65.2) Clinical Reference Target Range
Diagnostic / Lab Marker: Waist-to-Height Ratio [Obesity in Children E65.2] < 0.50 (E65.2) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Obesity in Children

Check Drug Interactions →
Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Benzphetamine Hydrochloride Benzphetamine Hydrochloride Generic • RxCUI 904368 Sympathomimetic Amine Anorectic 81% $3.0500 $ 132.03 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Obesity in Children)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Potent incretin-based therapy for: What a 5,140-Participant Study Found

The side effects related to semaglutide and tirzepatide were primarily of mild-to-moderate severity and mostly gastrointestinal, which was more frequent during the dose-titration period and leveled off during the treatment period.

Obesity reviews : an official journal of the International Association for the Study of Obesity • 2024-05-15 • Meta-Analysis
N = 5,140 99/100 PMID 38463003 ↗
New Insights on Tirzepatide as a novel effective and safe strategy for treating: What a 11,758-Participant Study Found

Tirzepatide, as a weight loss drug, significantly reduces BMI, waist circumference and body weight while gastrointestinal adverse reactions need to be vigilant.

Frontiers in public health • 2024-01-15 • Meta-Analysis
N = 11,758 99/100 PMID 38356942 ↗
New Insights on Comparative effectiveness of glucagon-like peptide-1 receptor agonists for the: What a 12,300-Participant Study Found

GLP-1RAs triggered more gastrointestinal side effects than placebo, with no in-between difference.

Obesity reviews : an official journal of the International Association for the Study of Obesity • 2023-03-15 • Meta-Analysis
N = 12,300 99/100 PMID 36579723 ↗
New Insights on Semaglutide and Exercise Function in Obesity-Related HFpEF: Insights From the: What a 1,145-Participant Study Found

In patients with obesity-related HFpEF, impaired 6MWD is most strongly associated with excess adiposity, congestion, and inflammation.

JACC. Heart failure • 2025-11-15 • Randomized Controlled Trial
N = 1,145 96/100 PMID 41045908 ↗
New Insights on Coadministered Cagrilintide and Semaglutide in Adults with Overweight or: What a 3,417-Participant Study Found

Cagrilintide-semaglutide provided significant and clinically relevant body-weight reductions in adults with overweight or obesity, as compared with placebo.

The New England journal of medicine • 2025-08-14 • Phase III Randomized Trial
N = 3,417 96/100 PMID 40544433 ↗
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