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Osteoarthritis, Gout & Joint Pain • ICD-10-CM M83.9

Osteomalacia

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM M83.9 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Osteomalacia Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Osteomalacia?

Osteomalacia is an ICD-10-CM indexed diagnosis (M83.9) within Osteoarthritis, Gout & Joint Pain. Clinical evaluation centers on synovial fluid crystal/cell in Osteomalacia (M83.9: analysis when effused) alongside serial hs-CRP & Erythrocyte in Osteomalacia (M83.9: Sedimentation Rate) tracking (hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M83.9)) to guide individualized care.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Osteomalacia (M83.9) center on low-grade synovial metalloproteinase in Osteomalacia (M83.9: release). targeted arthritis & joints interventions aim to normalize hs-CRP & Erythrocyte in Osteomalacia (M83.9: Sedimentation Rate).

Common Symptoms & Clinical Signs

  • • Presentation of Osteomalacia (M83.9): activity-related deep aching in Osteomalacia (M83.9: joint pain in)
  • • Secondary Osteomalacia clinical sign: brief morning joint in Osteomalacia (M83.9: stiffness)
  • • Symptom flares in Osteomalacia correlating with hs-CRP & Erythrocyte in Osteomalacia (M83.9: Sedimentation Rate) deviation outside hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M83.9)
  • • Functional arthritis & joints impact requiring synovial fluid crystal/cell in Osteomalacia (M83.9: analysis when effused) evaluation (M83.9)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Osteomalacia Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code M83.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Osteoarthritis, Gout & Joint Pain NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: hs-CRP & Erythrocyte in Osteomalacia (M83.9: Sedimentation Rate) hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M83.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Weight-Bearing Joint Radiograph [Osteomalacia M83.9] Preserved joint-space width (M83.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Uric Acid in Osteomalacia (M83.9: (Gout Target)) < 6.0 mg/dL (< 5.0 mg/dL with tophi) (M83.9) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Osteomalacia

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Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Osteomalacia)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Age on the real-world benefits and safety of peficitinib (ASP015K) for the

Peficitinib was efficacious in adult Asian RA patients of all ages.

Modern rheumatology • 2022-07-01 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 34850095 ↗
Can This Approach Help? Inside the Latest Research on Efficacy of baricitinib in patients with moderate-to-severe autoimmune joint pain

Treatment with baricitinib 4 mg demonstrated efficacy for up to 3 years and was well tolerated.

Rheumatology (Oxford, England) • 2021-05-14 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 33200220 ↗
What the Latest Evidence Really Says About Association between statin use and incidence or progression of wear-and-tear

Statin use may not be associated with a lower risk of incidence and progression of OA, regardless of joint site.

Osteoarthritis and cartilage • 2020-09-15 • Meta-Analysis
Multi-cohort 86/100 PMID 32360737 ↗
Can This Approach Help? Inside the Latest Research on Exploratory analysis of the potential disconnect between objective inflammatory

There is a potential disconnect between objective measures of inflammation and clinical outcome responses in patients with axSpA.

RMD open • 2024-08-28 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 39209369 ↗
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