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Dermatology: Acne, Eczema, Psoriasis & Rosacea • ICD-10-CM L56.4

Polymorphous light eruption

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM L56.4 • 8 Linked .gov / PubMed Citations • Governance: Dr. Priya Nair, MD, FAAD (NPI #1295730425)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Polymorphous light eruption Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Polymorphous light eruption?

Physicians managing Polymorphous light eruption (L56.4; Dermatology: Acne, Eczema, Psoriasis & Rosacea) utilize dermoscopy or punch in Polymorphous light eruption (L56.4: biopsy when atypical) and objective Fasting Lipids & in Polymorphous light eruption (L56.4: ALT (if systemic) targets (Within baseline reference limits (L56.4)) to prevent progression and functional morbidity.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Polymorphous light eruption (L56.4) center on or pilosebaceous follicular in Polymorphous light eruption (L56.4: hyperkeratinization). targeted skin & dermatology interventions aim to normalize Fasting Lipids & in Polymorphous light eruption (L56.4: ALT (if systemic).

Common Symptoms & Clinical Signs

  • • Presentation of Polymorphous light eruption (L56.4): persistent erythematous plaques, in Polymorphous light eruption (L56.4: scaly patches, pruritic)
  • • Secondary Polymorphous light eruption clinical sign: compromised epidermal barrier in Polymorphous light eruption (L56.4: with dryness, fissuring,)
  • • Symptom flares in Polymorphous light eruption correlating with Fasting Lipids & in Polymorphous light eruption (L56.4: ALT (if systemic) deviation outside Within baseline reference limits (L56.4)
  • • Functional skin & dermatology impact requiring dermoscopy or punch in Polymorphous light eruption (L56.4: biopsy when atypical) evaluation (L56.4)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Polymorphous light eruption Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code L56.4 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Dermatology: Acne, Eczema, Psoriasis & Rosacea NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Fasting Lipids & in Polymorphous light eruption (L56.4: ALT (if systemic) Within baseline reference limits (L56.4) Clinical Reference Target Range
Diagnostic / Lab Marker: 25-Hydroxy Vitamin D in Polymorphous light eruption (L56.4: & hs-CRP) 25(OH)D 40–65 ng/mL (L56.4) Clinical Reference Target Range
Diagnostic / Lab Marker: Affected Body Surface in Polymorphous light eruption (L56.4: Area (BSA /) Clear or Almost Clear (IGA 0–1) (L56.4) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Polymorphous light eruption

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Treatment selection for Polymorphous light eruption depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Polymorphous light eruption)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Secukinumab maintains superiority over ustekinumab in clearing skin and improving: What a 550-Participant Study Found

This second head-to-head study confirmed the superior efficacy of secukinumab over ustekinumab in skin clearance and quality of life through 52 weeks, with safety comparable to that reported in previous trials.

Journal of the European Academy of Dermatology and Venereology : JEADV • 2021-01-15 • Phase III Randomized Trial
N = 550 93/100 PMID 32365251 ↗
New Insights on Efficacy, Safety and Immunogenicity of AVT02 Versus Originator Adalimumab in: What a 413-Participant Study Found

Objective and subjective measures of efficacy supported the evaluation of biosimilarity between AVT02 and originator adalimumab at Week 16 and until Week 50, in switched and continued treatment groups.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy • 2021-11-15 • Phase III Randomized Trial
N = 413 93/100 PMID 34657274 ↗
Can This Approach Help? Inside the Latest Research on Treatment of severe cystic acne with 13-cis-retinoic acid. Evaluation of sebum

The most common clinical side effects were cheilitis, desquamation of the skin, and severe itching, but the side effects were not severe enough to require interruption of treatment.

Journal of the American Academy of Dermatology • 1980-12-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 6451637 ↗
What the Latest Evidence Really Says About Comorbidities Associated With Lichen

LPP is significantly associated with autoimmune disorders, thyroid diseases, and skin cancer.

International journal of dermatology • 2025-12-15 • Meta-Analysis
Multi-cohort 86/100 PMID 40579650 ↗
What the Latest Evidence Really Says About Eczema: global epidemiology and risk

AD has been described as an allergic skin disease, but today, the contribution of allergic reactions to the initiation of AD is challenged, and it is proposed that allergy is rather a consequence of AD in subjects with a...

Annals of nutrition & metabolism • 2015-01-15 • Meta-Analysis
Multi-cohort 86/100 PMID 25925336 ↗
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