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Osteoarthritis, Gout & Joint Pain • ICD-10-CM M31.4

Takayasu's arteritis

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM M31.4 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Takayasu's arteritis Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Takayasu's arteritis?

Takayasu's arteritis—coded clinically as M31.4 across Arthritis & Joints guidelines—combines serum urate/inflammatory marker in Takayasu's arteritis (M31.4: profiling) with structured follow-up of Serum Uric Acid in Takayasu's arteritis (M31.4: (Gout Target)) (< 6.0 mg/dL (< 5.0 mg/dL with tophi) (M31.4)).

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in arthritis & joints, Takayasu's arteritis (M31.4) involves monosodium urate or in Takayasu's arteritis (M31.4: calcium pyrophosphate crystal). progression correlates with shifts in Weight-Bearing Joint Radiograph [Takayasu's arteritis M31.4] (Preserved joint-space width (M31.4)).

Common Symptoms & Clinical Signs

  • • Presentation of Takayasu's arteritis (M31.4): localized tendon or in Takayasu's arteritis (M31.4: bursa tenderness limiting)
  • • Secondary Takayasu's arteritis clinical sign: activity-related deep aching in Takayasu's arteritis (M31.4: joint pain in)
  • • Symptom flares in Takayasu's arteritis correlating with Weight-Bearing Joint Radiograph [Takayasu's arteritis M31.4] deviation outside Preserved joint-space width (M31.4)
  • • Functional arthritis & joints impact requiring serum urate/inflammatory marker in Takayasu's arteritis (M31.4: profiling) evaluation (M31.4)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Takayasu's arteritis Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code M31.4 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Osteoarthritis, Gout & Joint Pain NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Weight-Bearing Joint Radiograph [Takayasu's arteritis M31.4] Preserved joint-space width (M31.4) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Uric Acid in Takayasu's arteritis (M31.4: (Gout Target)) < 6.0 mg/dL (< 5.0 mg/dL with tophi) (M31.4) Clinical Reference Target Range
Diagnostic / Lab Marker: hs-CRP & Erythrocyte in Takayasu's arteritis (M31.4: Sedimentation Rate) hs-CRP < 1.5 mg/L; ESR < 15 mm/hr (M31.4) Clinical Reference Target Range
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Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Takayasu's arteritis)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Deciphering differential biomarkers for anti-interleukin-6 receptor and: What a 804-Participant Study Found

The unbiased analysis of serum proteins identified biomarkers most predictive of anti-IL-6R and anti-TNF-α at different timepoints that could explain the difference in the response rate in patients with RA.

RMD open • 2025-08-04 • Phase III Randomized Trial
N = 804 93/100 PMID 40759562 ↗
Can This Approach Help? Inside the Latest Research on Promising efficacy of coenzyme Q10 supplementation as add-on treatment in

CoQ10 significantly improved disease severity, QoL, and inflammatory and oxidative stress markers in JIA patients with an excellent safety profile.

Immunopharmacology and immunotoxicology • 2026-06-15 • Phase III Randomized Trial
N = 58 88/100 PMID 41958203 ↗
Can This Approach Help? Inside the Latest Research on Benefits and safety of curcumin in maintaining full symptom relief during

No serious adverse effects were noted.

Rheumatology international • 2023-12-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 37650921 ↗
Can This Approach Help? Inside the Latest Research on Vascular imaging of patients with refractory Takayasu arteritis treated with

Approximately 60% of patients with TAK did not experience progression in wall thickness within 96 weeks after initiation of tocilizumab treatment.

Rheumatology (Oxford, England) • 2022-05-30 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 34528074 ↗
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