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Ear, Nose, Throat & Oral Health • ICD-10-CM J35.1

Tonsils - large

Also known as: Macro, Large

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM J35.1 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Tonsils - large Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Tonsils - large?

Physicians managing Tonsils - large (also termed Macro or Large) (J35.1; Ear, Nose, Throat & Oral Health) utilize hearing protection/amplification [Tonsils - large J35.1] and objective Pure-Tone Audiometry & in Tonsils - large (J35.1: Tympanometry) targets (Thresholds <= 20 dB HL; normal middle-ear pressure (J35.1)) to prevent progression and functional morbidity.

Pathophysiology, Underlying Causes & Clinical Presentation

Tonsils - large (J35.1) alters ent & hearing homeostasis through Eustachian tube dysfunction [Tonsils - large J35.1]; clinical remission targets Periodontal Pocket Depth in Tonsils - large (J35.1: & Bleeding Index) within Probing <= 3 mm without bleeding (J35.1).

Common Symptoms & Clinical Signs

  • • Presentation of Tonsils - large (J35.1): muffled hearing, ear in Tonsils - large (J35.1: fullness, popping pressure,)
  • • Secondary Tonsils - large clinical sign: acute earache, sore in Tonsils - large (J35.1: throat with painful)
  • • Symptom flares in Tonsils - large correlating with Pure-Tone Audiometry & in Tonsils - large (J35.1: Tympanometry) deviation outside Thresholds <= 20 dB HL; normal middle-ear pressure (J35.1)
  • • Functional ent & hearing impact requiring hearing protection/amplification [Tonsils - large J35.1] evaluation (J35.1)

Tonsils - large Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code J35.1 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Ear, Nose, Throat & Oral Health NLM Clinical Tables
Diagnostic / Lab Marker: Pure-Tone Audiometry & in Tonsils - large (J35.1: Tympanometry) Thresholds <= 20 dB HL; normal middle-ear pressure (J35.1) Clinical Reference Target Range
Diagnostic / Lab Marker: Periodontal Pocket Depth in Tonsils - large (J35.1: & Bleeding Index) Probing <= 3 mm without bleeding (J35.1) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Tonsils - large

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Small and Large Intestine Sarcode (Colon (Suis), Intestine (Suis)) Small and Large Intestine Sarcode • RxCUI RXN-B830270065 Over-the-Counter Clinical Monograph 81% $1.5000 $ 116.50 /mo
Sodium Phosphates Sodium Phosphates Generic • RxCUI 1872384 FDA Prescription Therapeutic Agent 89% $2.2300 $ 98.82 /mo
Sodium Acetate Sodium Acetate Generic • RxCUI 1859490 Osmotic Laxative 81% $1.5600 $ 71.68 /mo
Potassium Acetate Potassium Acetate Generic • RxCUI 1871155 Osmotic Laxative 87% $0.4600 $ 27.13 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Tonsils - large)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Sustained real-world benefits and safety of guselkumab in patients with

The majority of treatment-emergent side effects (TEAE) were mild to moderate (~88%) with low incidence of serious TEAE (7.6%).

The Journal of dermatology • 2021-12-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 34453358 ↗
New Insights on Ivermectin Accelerates Circulating Nonstructural Protein 1 (NS1) Clearance in: What a 203-Participant Study Found

A 3-day 1 daily dose of 400 µg/kg oral ivermectin was safe and accelerated NS1 antigenemia clearance in dengue patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2021-05-18 • Phase III Randomized Trial
N = 203 88/100 PMID 33462580 ↗
New Insights on Twenty-year survival of advanced gastrointestinal stromal tumours treated with: What a 434-Participant Study Found

This long-term follow-up of the BFR14 trial shows long-term efficacy of imatinib in patients with advanced GIST.

Annals of oncology : official journal of the European Society for Medical Oncology • 2025-09-15 • Phase III Randomized Trial
N = 434 87/100 PMID 40447230 ↗
Can This Approach Help? Inside the Latest Research on Gene Expression Signatures Predict First-Year Response to Somapacitan Treatment

Pretreatment transcriptome predicts first-year growth response in somapacitan-treated children with GHD.

The Journal of clinical endocrinology and metabolism • 2024-04-19 • Phase III Randomized Trial
N = 76 82/100 PMID 38066644 ↗
Can This Approach Help? Inside the Latest Research on Effects of telmisartan on the nuclear factor of activated T lymphocytes

Blood-pressure-lowering function and inhibitory effects of telmisartan on the T lymphocyte NFAT signalling pathway are unlikely to affect the normal immune function of hypertensive patients.

Journal of the renin-angiotensin-aldosterone system : JRAAS • 2016-01-15 • Randomized Controlled Trial
Multi-cohort 82/100 PMID 27317303 ↗
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