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Acid Reflux, GERD & Upper GI Health • ICD-10-CM K22.10

Ulcer of esophagus without bleeding

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM K22.10 • 7 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Ulcer of esophagus without bleeding Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Ulcer of esophagus without bleeding?

Physicians managing Ulcer of esophagus without bleeding (K22.10; Acid Reflux, GERD & Upper GI Health) utilize alarm-symptom upper endoscopy in Ulcer of esophagus without bleeding (K22.10: (EGD) triage) and objective H. pylori Stool in Ulcer of esophagus without bleeding (K22.10: Antigen or Urea) targets (Negative (K22.10)) to prevent progression and functional morbidity.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Ulcer of esophagus without bleeding (ICD-10 K22.10) is driven by transient lower esophageal in Ulcer of esophagus without bleeding (K22.10: sphincter relaxation); specialists in Acid Reflux, GERD & Upper GI Health monitor Hemoglobin & Serum in Ulcer of esophagus without bleeding (K22.10: Ferritin) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Presentation of Ulcer of esophagus without bleeding (K22.10): chronic throat clearing, in Ulcer of esophagus without bleeding (K22.10: hoarseness, nocturnal cough,)
  • • Secondary Ulcer of esophagus without bleeding clinical sign: nausea, belching, or in Ulcer of esophagus without bleeding (K22.10: discomfort relieved or)
  • • Symptom flares in Ulcer of esophagus without bleeding correlating with H. pylori Stool in Ulcer of esophagus without bleeding (K22.10: Antigen or Urea) deviation outside Negative (K22.10)
  • • Functional gerd & stomach impact requiring alarm-symptom upper endoscopy in Ulcer of esophagus without bleeding (K22.10: (EGD) triage) evaluation (K22.10)

Ulcer of esophagus without bleeding Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code K22.10 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Acid Reflux, GERD & Upper GI Health NLM Clinical Tables
Diagnostic / Lab Marker: H. pylori Stool in Ulcer of esophagus without bleeding (K22.10: Antigen or Urea) Negative (K22.10) Clinical Reference Target Range
Diagnostic / Lab Marker: Hemoglobin & Serum in Ulcer of esophagus without bleeding (K22.10: Ferritin) Ferritin > 50 ng/mL (no occult loss) (K22.10) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Vitamin B12 in Ulcer of esophagus without bleeding (K22.10: & Magnesium (chronic) B12 > 450 pg/mL; Mg >= 2.0 mg/dL (K22.10) Clinical Reference Target Range
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Treatment selection for Ulcer of esophagus without bleeding depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Ulcer of esophagus without bleeding)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Benefits and safety of Tofacitinib in Ulcerative Colitis Based on Prior Tumor: What a 1,139-Participant Study Found

Tofacitinib was efficacious in patients with UC regardless of prior TNFi failure status.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association • 2022-03-15 • Phase III Randomized Trial
N = 1,139 96/100 PMID 33684552 ↗
New Insights on Vonoprazan non-inferior to lansoprazole in treating duodenal ulcer and: What a 263-Participant Study Found

Vonoprazan was well tolerated and non-inferior to lansoprazole for duodenal ulcer healing and achieved H.

Journal of gastroenterology and hepatology • 2022-07-15 • Phase III Randomized Trial
N = 263 93/100 PMID 35342997 ↗
New Insights on Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events: What a 787-Participant Study Found

Patients receiving etrasimod demonstrated no increased risk of infection.

Journal of Crohn's & colitis • 2024-10-15 • Phase III Randomized Trial
N = 787 93/100 PMID 38700040 ↗
New Insights on Effect and safety of anaprazole in the treatment of duodenal ulcers: a: What a 448-Participant Study Found

The efficacy of anaprazole is non-inferior to that of rabeprazole in Chinese patients with duodenal ulcers.

Chinese medical journal • 2022-12-20 • Phase III Randomized Trial
N = 448 93/100 PMID 36580650 ↗
New Insights on Long-term safety and real-world benefits of filgotinib for the treatment of: What a 250-Participant Study Found

Filgotinib induced and maintained symptomatic full symptom relief and improved HRQoL over 4 years.

Alimentary pharmacology & therapeutics • 2024-09-15 • Phase III Randomized Trial
N = 250 93/100 PMID 39086130 ↗
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