Alcohol

Dehydrated alcohol injection is indicated to induce controlled cardiac septal infarction to improve exercise capacity in adults with symptomatic hypertrophic obstructive cardiomyopathy who are not candidates for surgical myectomy. Dehydrated alcohol injection is an ablative agent indicated to induce controlled cardiac septal infarction to improve exercise capacity in adults with symptomatic hypertrophic obstructive cardiomyopathy who are not candidates for surgical myectomy. ( 1 )

12.1 Mechanism of Action Dehydrated alcohol is a tissue toxin that produces a myocardial infarction when injected through an intra-arterial catheter into a target septal vessel, which causes the hypertrophied septum to thin.

Clinical clearance of Alcohol (Over-the-Counter Clinical Monograph) relies on mixed metabolic conjugation and unchanged urinary excretion across alcohol regimens with a Terminal t½ estimated at 4–17 hrs depending on renal/hepatic reserve (Alcohol) half-life; patients absorbing at F ≈ 79%–91% systemic availability after standard oral Alcohol administration bioavailability typically observe target onset around time to peak concentration spans 1 to 2 hrs under alcohol maintenance.

FDA clinical labeling for Alcohol restricts administration in prior anaphylaxis, angioedema, or severe hypersensitivity to alcohol or alcohol excipients; co-administration with prohibited interacting drugs or decompensated organ failure per 2026-08-27 alcohol spl across .7 mL/mL Cloth, 62 mL/100mL Gel, 50 mL/100mL Liquid, 62 mL/100mL Spray, .6 kg/kg Liquid, with self-reported patient tracking dominated by nausea (8.3% of reports), headache (8.1% of reports), fatigue (5.7% of reports).